LPAR2

Lysophosphatidic acid receptor 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4P0C​
Identifiers
Symbols	LPAR2 ; EDG-4; EDG4; LPA-2; LPA2
External IDs	OMIM: 605110 MGI: 1858422 HomoloGene: 3465 IUPHAR: 273 ChEMBL: 3724 GeneCards: LPAR2 Gene
Gene ontology Molecular function • G-protein coupled receptor activity • protein binding • lipid binding • PDZ domain binding • lysophosphatidic acid receptor activity Cellular component • cytosol • plasma membrane • integral component of plasma membrane • cell surface • endocytic vesicle Biological process • activation of MAPK activity • G-protein coupled receptor signaling pathway • activation of phospholipase C activity • positive regulation of cytosolic calcium ion concentration • positive regulation of Rho protein signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9170	53978
Ensembl	ENSG00000064547	ENSMUSG00000031861
UniProt	Q9HBW0	E9QJW6
RefSeq (mRNA)	NM_004720	NM_020028
RefSeq (protein)	NP_004711	NP_064412
Location (UCSC)	Chr 19: 19.62 – 19.63 Mb	Chr 8: 69.82 – 69.83 Mb
PubMed search

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene.^[1][2][3] LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[4]

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca²⁺ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.^[1]

Interactions

LPAR2 has been shown to interact with TRIP6.^[5]

See also

• Lysophospholipid receptor

References

1. "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".
2. An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886.
3. An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. PMID 9804623.
4. Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
5. Xu, Jun; Lai Yun-Ju; Lin Weei-Chin; Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. (United States) 279 (11): 10459–68. doi:10.1074/jbc.M311891200. ISSN 0021-9258. PMID 14688263.

Further reading

• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54–60. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441.
• Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors.". Mol. Pharmacol. 58 (6): 1188–96. PMID 11093753.
• Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.". Cancer Res. 59 (20): 5370–5. PMID 10537322.
• Contos JJ, Chun J (2000). "Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA.". Genomics 64 (2): 155–69. doi:10.1006/geno.2000.6122. PMID 10729222.
• Bandoh K, Aoki J, Taira A, et al. (2000). "Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors.". FEBS Lett. 478 (1–2): 159–65. doi:10.1016/S0014-5793(00)01827-5. PMID 10922489.
• Young KW, Bootman MD, Channing DR, et al. (2001). "Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors.". J. Biol. Chem. 275 (49): 38532–9. doi:10.1074/jbc.M006631200. PMID 10954727.
• Zheng Y, Voice JK, Kong Y, Goetzl EJ (2001). "Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes.". FASEB J. 14 (15): 2387–9. doi:10.1096/fj.00-0492fje. PMID 11024010.
• Hama K, Bandoh K, Kakehi Y, et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.". FEBS Lett. 523 (1–3): 187–92. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fujita T, Miyamoto S, Onoyama I, et al. (2003). "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer.". Cancer Lett. 192 (2): 161–9. doi:10.1016/S0304-3835(02)00713-9. PMID 12668280.
• Hu YL, Albanese C, Pestell RG, Jaffe RB (2003). "Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells.". J. Natl. Cancer Inst. 95 (10): 733–40. doi:10.1093/jnci/95.10.733. PMID 12759391.
• Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.". J. Biol. Chem. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Oh YS, Jo NW, Choi JW, et al. (2004). "NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.". Mol. Cell. Biol. 24 (11): 5069–79. doi:10.1128/MCB.24.11.5069-5079.2004. PMC 416407. PMID 15143197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• "Lysophospholipid Receptors: LPA₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Lysophospholipid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.