MASTL

Microtubule associated serine/threonine kinase-like
Identifiers
Symbols	MASTL ; GREATWALL; GW; GWL; MAST-L; THC2; hGWL
External IDs	OMIM: 608221 MGI: 1914371 HomoloGene: 12086 GeneCards: MASTL Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • ATP binding • kinase activity • protein phosphatase 2A binding Cellular component • nucleus • nucleoplasm • cytoplasm • centrosome • cleavage furrow Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • cellular response to DNA damage stimulus • mitotic nuclear division • regulation of mitotic nuclear division • female meiosis II • peptidyl-serine phosphorylation • negative regulation of protein phosphatase type 2A activity • intracellular signal transduction • regulation of meiotic nuclear division • cell division • activation of anaphase-promoting complex activity involved in meiotic cell cycle • regulation of cell cycle Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84930	67121
Ensembl	ENSG00000120539	ENSMUSG00000026779
UniProt	Q96GX5	Q8C0P0
RefSeq (mRNA)	NM_001172303	NM_025979
RefSeq (protein)	NP_001165774	NP_080255
Location (UCSC)	Chr 10: 27.15 – 27.19 Mb	Chr 2: 23.12 – 23.16 Mb
PubMed search

Microtubule-associated serine/threonine-protein kinase-like is an enzyme that in humans is encoded by the MASTL gene.^[1]

References

1. "Entrez Gene: MASTL microtubule associated serine/threonine kinase-like".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Savoia A, Del Vecchio M, Totaro A, et al. (1999). "An autosomal dominant thrombocytopenia gene maps to chromosomal region 10p". Am. J. Hum. Genet. 65 (5): 1401–5. doi:10.1086/302637. PMC 1288293. PMID 10521306.
• Drachman JG, Jarvik GP, Mehaffey MG (2000). "Autosomal dominant thrombocytopenia: incomplete megakaryocyte differentiation and linkage to human chromosome 10". Blood 96 (1): 118–25. PMID 10891439.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gandhi MJ, Cummings CL, Drachman JG (2004). "FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10". Hum. Hered. 55 (1): 66–70. doi:10.1159/000071812. PMID 12890928.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.