PRKCB1

Protein kinase C, beta
PDB rendering based on 1a25.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2I0E​
Identifiers
Symbols	PRKCB ; PKC-beta; PKCB; PRKCB1; PRKCB2
External IDs	OMIM: 176970 MGI: 97596 HomoloGene: 56424 ChEMBL: 3045 GeneCards: PRKCB Gene
EC number	2.7.11.13
Gene ontology Molecular function • chromatin binding • protein serine/threonine kinase activity • protein kinase C activity • protein kinase C binding • calcium channel regulator activity • protein binding • ATP binding • zinc ion binding • ligand-dependent nuclear receptor transcription coactivator activity • histone kinase activity (H3-T6 specific) • histone binding • androgen receptor binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol • plasma membrane • extracellular exosome Biological process • mitotic cell cycle • adaptive immune response • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • protein phosphorylation • calcium ion transport • cellular calcium ion homeostasis • apoptotic process • mitotic nuclear envelope disassembly • signal transduction • synaptic transmission • blood coagulation • negative regulation of glucose transport • platelet activation • positive regulation of vascular endothelial growth factor receptor signaling pathway • histone H3-T6 phosphorylation • intracellular signal transduction • B cell activation • lipoprotein transport • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of angiogenesis • negative regulation of insulin receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • B cell receptor signaling pathway • positive regulation of B cell receptor signaling pathway • positive regulation of NF-kappaB transcription factor activity • cellular response to carbohydrate stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5579	18751
Ensembl	ENSG00000166501	ENSMUSG00000052889
UniProt	P05771	P68404
RefSeq (mRNA)	NM_002738	NM_008855
RefSeq (protein)	NP_002729	NP_032881
Location (UCSC)	Chr 16: 23.84 – 24.22 Mb	Chr 7: 122.29 – 122.63 Mb
PubMed search

Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene.^[1]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[2] This gene could be associated with autism.^{[3] [4]}

Interactions

PRKCB1 has been shown to interact with RIPK4,^[5] Beta adrenergic receptor kinase,^[6] PDLIM5^[7] and GNB2L1.^[8]

References

1. Kubo K, Ohno S, Suzuki K; Ohno; Suzuki (November 1987). "Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II". Nucleic Acids Res 15 (17): 7179–80. doi:10.1093/nar/15.17.7179. PMC 306204. PMID 3658678.
2. "Entrez Gene: PRKCB1 protein kinase C, beta 1".
3. Philippi, A; Roschmann, E; Tores, F; Lindenbaum, P; Benajou, A; Germain-Leclerc, L; Marcaillou, C; Fontaine, K; et al. (October 2005). "Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism". Mol. Psychiatry 10 (10): 950–60. doi:10.1038/sj.mp.4001704. PMID 16027742.
4. Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C, Curatolo P, Manzi B, Schneider C, Melmed R, Elia M, Pascucci T, S Puglisi-Allegra, K-L Reichelt, Persico AM (2009). "Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression". Mol Psychiatry 14 (7): 705–718. doi:10.1038/mp.2008.21. PMID 18317465.
5. Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. PMID 11278382.
6. Yang, Xing-Long; Zhang Ya-Li; Lai Zhuo-Sheng; Xing Fei-Yue; Liu Yu-Hu (April 2003). "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase". World J. Gastroenterol. 9 (4): 800–3. PMID 12679936.
7. Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. PMID 8940095.
8. Ron, D; Jiang Z; Yao L; Vagts A; Diamond I; Gordon A (September 1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem. 274 (38): 27039–46. doi:10.1074/jbc.274.38.27039. PMID 10480917.

Further reading

• Mochly-Rosen D (1995). "Localization of protein kinases by anchoring proteins: a theme in signal transduction". Science 268 (5208): 247–51. doi:10.1126/science.7716516. PMID 7716516.
• Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
• Slater SJ, Ho C, Stubbs CD (2003). "The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions". Chem. Phys. Lipids 116 (1–2): 75–91. doi:10.1016/S0009-3084(02)00021-X. PMID 12093536.

See also

• Protein kinase C