Casein kinase 2

The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.

Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation.^[1] A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.

Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.^[2]

casein kinase 2, alpha 1 polypeptide Identifiers Symbol CSNK2A1 Entrez 1457 HUGO 2457 OMIM 115440 RefSeq NM_001895 UniProt P68400 Other data EC number 2.7.11.1 Locus Chr. 20 p13

casein kinase 2, alpha prime polypeptide Identifiers Symbol CSNK2A2 Entrez 1459 HUGO 2459 OMIM 115442 RefSeq NM_001896 UniProt P19784 Other data EC number 2.7.11.1 Locus Chr. 16

casein kinase 2, beta polypeptide Identifiers Symbol CSNK2B Entrez 1460 HUGO 2460 OMIM 115441 RefSeq NM_001320 UniProt P67870 Other data EC number 2.7.11.1 Locus Chr. 6 p21.3

See also

• CSNK2A1
• CSNK2A2
• Casein kinase 1 — a distinct protein kinase family

References

1. Gao Y, Wang HY (July 2006). "Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling". J. Biol. Chem. 281 (27): 18394–400. doi:10.1074/jbc.M601112200. PMID 16672224.
2. Xu X, Toselli PA, Russell LD, Seldin DC (September 1999). "Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit". Nat. Genet. 23 (1): 118–21. doi:10.1038/12729. PMID 10471512.