ACVR1C

Activin A receptor, type IC
Identifiers
Symbols	ACVR1C ; ACVRLK7; ALK7
External IDs	OMIM: 608981 MGI: 2661081 HomoloGene: 26724 IUPHAR: 1790 ChEMBL: 5642 GeneCards: ACVR1C Gene
EC number	2.7.11.30
Gene ontology Molecular function • receptor signaling protein serine/threonine kinase activity • ATP binding • activin receptor activity, type I • growth factor binding • nodal binding • metal ion binding Cellular component • plasma membrane • activin receptor complex Biological process • response to dietary excess • protein phosphorylation • response to glucose • lipid storage • signal transduction by protein phosphorylation • cell differentiation • apoptotic nuclear changes • response to insulin • nodal signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of insulin secretion • negative regulation of trophoblast cell migration • negative regulation of chorionic trophoblast cell proliferation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	130399	269275
Ensembl	ENSG00000123612	ENSMUSG00000026834
UniProt	Q8NER5	Q8K348
RefSeq (mRNA)	NM_001111031	NM_001033369
RefSeq (protein)	NP_001104501	NP_001028541
Location (UCSC)	Chr 2: 157.53 – 157.63 Mb	Chr 2: 58.27 – 58.36 Mb
PubMed search

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.^[1] ACVR1C is a type I receptor for the TGFB family of signaling molecules.^[1]

ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.^[2]

Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.^[1]

References

1. Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O (2001). "cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)". Cytogenet. Cell Genet. 95 (3–4): 157–62. doi:10.1159/000059339. PMID 12063393.
2. Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS (July 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol. 62 (1): 65–74. doi:10.1124/mol.62.1.65. PMID 12065756.

Further reading

• Carlsson LM, Jacobson P, Walley A; et al. (2009). "ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease". Biochem. Biophys. Res. Commun. 382 (2): 309–14. doi:10.1016/j.bbrc.2009.03.014. PMC 2681012. PMID 19275893.
• Reissmann E, Jörnvall H, Blokzijl A; et al. (2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development". Genes Dev. 15 (15): 2010–22. doi:10.1101/gad.201801. PMC 312747. PMID 11485994.
• Andersson O, Korach-Andre M, Reissmann E; et al. (2008). "Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity". Proc. Natl. Acad. Sci. U.S.A. 105 (20): 7252–6. doi:10.1073/pnas.0800272105. PMC 2438236. PMID 18480259.
• Watanabe R, Shen ZP, Tsuda K, Yamada Y (2008). "Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells". Biochem. Biophys. Res. Commun. 377 (3): 867–72. doi:10.1016/j.bbrc.2008.10.074. PMID 18951876.
• Roberts HJ, Hu S, Qiu Q; et al. (2003). "Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta". Biol. Reprod. 68 (5): 1719–26. doi:10.1095/biolreprod.102.013045. PMID 12606401.
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Xu G, Zhong Y, Munir S; et al. (2004). "Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7". J. Clin. Endocrinol. Metab. 89 (11): 5523–34. doi:10.1210/jc.2004-0893. PMID 15531507.
• Xu G, Bernaudo S, Fu G; et al. (2008). "Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7". Mol. Biol. Cell 19 (11): 4968–79. doi:10.1091/mbc.E08-03-0259. PMC 2575152. PMID 18784254.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim BC, van Gelder H, Kim TA; et al. (2004). "Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells". J. Biol. Chem. 279 (27): 28458–65. doi:10.1074/jbc.M313277200. PMID 15107418.
• Munir S, Xu G, Wu Y; et al. (2004). "Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells". J. Biol. Chem. 279 (30): 31277–86. doi:10.1074/jbc.M400641200. PMID 15150278.
• Xu G, Zhou H, Wang Q; et al. (2006). "Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines". Mol. Cancer Res. 4 (4): 235–46. doi:10.1158/1541-7786.MCR-05-0174. PMID 16603637.
• Tsuchida K, Nakatani M, Yamakawa N; et al. (2004). "Activin isoforms signal through type I receptor serine/threonine kinase ALK7". Mol. Cell. Endocrinol. 220 (1–2): 59–65. doi:10.1016/j.mce.2004.03.009. PMID 15196700.