KIF1B

Kinesin family member 1B
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EH0​
Identifiers
Symbols	KIF1B ; CMT2; CMT2A; CMT2A1; HMSNII; KLP; NBLST1
External IDs	OMIM: 605995 MGI: 108426 HomoloGene: 99835 ChEMBL: 5889 GeneCards: KIF1B Gene
Gene ontology Molecular function • microtubule motor activity • protein binding • ATP binding • microtubule binding • ATP-dependent microtubule motor activity, plus-end-directed • ATPase activity • kinesin binding Cellular component • mitochondrion • kinesin complex • microtubule • microtubule associated complex • cytoplasmic vesicle membrane • cytoplasmic vesicle • neuron projection Biological process • apoptotic process • microtubule-based movement • neuron-neuron synaptic transmission • neuromuscular synaptic transmission • anterograde axon cargo transport • metabolic process • vesicle-mediated transport • cytoskeleton-dependent intracellular transport • mitochondrion transport along microtubule Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23095	16561
Ensembl	ENSG00000054523	ENSMUSG00000063077
UniProt	O60333	Q60575
RefSeq (mRNA)	NM_015074	NM_001290995
RefSeq (protein)	NP_055889	NP_001277924
Location (UCSC)	Chr 1: 10.21 – 10.38 Mb	Chr 4: 149.18 – 149.31 Mb
PubMed search

Kinesin-like protein KIF1B is a protein that in humans is encoded by the KIF1B gene.^[1][2][3]

Clinical significance

It is associated with Charcot–Marie–Tooth disease, type 2A1.^[3]

Interactions

KIF1B has been shown to interact with GIPC1.^[4]

References

1. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N (Jun 2001). "Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta". Cell 105 (5): 587–97. doi:10.1016/S0092-8674(01)00363-4. PMID 11389829.
2. Nagai M, Ichimiya S, Ozaki T, Seki N, Mihara M, Furuta S, Ohira M, Tomioka N, Nomura N, Sakiyama S, Kubo O, Takakura K, Hori T, Nakagawara A (May 2000). "Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2". Int J Oncol 16 (5): 907–16. doi:10.3892/ijo.16.5.907. PMID 10762626.
3. "Entrez Gene: KIF1B kinesin family member 1B".
4. Bunn, R C; Jensen M A; Reed B C (Apr 1999). "Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton". Mol. Biol. Cell 10 (4): 819–32. doi:10.1091/mbc.10.4.819. ISSN 1059-1524. PMC 25204. PMID 10198040.

Further reading

• Nangaku M, Sato-Yoshitake R, Okada Y, et al. (1995). "KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria". Cell 79 (7): 1209–20. doi:10.1016/0092-8674(94)90012-4. PMID 7528108.
• Gong TL, Burmeister M, Lomax MI (1997). "The novel gene D4Mil1e maps to mouse chromosome 4 and human chromosome 1p36". Mamm. Genome 7 (10): 790–1. doi:10.1007/s003359900237. PMID 8854876.
• Saito M, Hayashi Y, Suzuki T, et al. (1998). "Linkage mapping of the gene for Charcot-Marie-Tooth disease type 2 to chromosome 1p (CMT2A) and the clinical features of CMT2A". Neurology 49 (6): 1630–5. doi:10.1212/wnl.49.6.1630. PMID 9409358.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Bunn RC, Jensen MA, Reed BC (1999). "Protein Interactions with the Glucose Transporter Binding Protein GLUT1CBP That Provide a Link between GLUT1 and the Cytoskeleton". Mol. Biol. Cell 10 (4): 819–32. doi:10.1091/mbc.10.4.819. PMC 25204. PMID 10198040.
• Conforti L, Buckmaster EA, Tarlton A, et al. (1999). "The major brain isoform of kif1b lacks the putative mitochondria-binding domain". Mamm. Genome 10 (6): 617–22. doi:10.1007/s003359901056. PMID 10341097.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Yang HW, Chen YZ, Takita J, et al. (2001). "Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2". Oncogene 20 (36): 5075–83. doi:10.1038/sj.onc.1204456. PMID 11526494.
• Mok H, Shin H, Kim S, et al. (2002). "Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins". J. Neurosci. 22 (13): 5253–8. PMID 12097473.
• Nakamura N, Miyake Y, Matsushita M, et al. (2003). "KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles". J. Biochem. 132 (3): 483–91. doi:10.1093/oxfordjournals.jbchem.a003246. PMID 12204119.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMC 196011. PMID 12629046.
• Chen YY, Takita J, Chen YZ, et al. (2004). "Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma". Int. J. Oncol. 23 (3): 737–44. doi:10.3892/ijo.23.3.737. PMID 12888911.
• Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
• Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.

External links

• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 2