KRT85

Keratin 85, type II
Identifiers
Symbols	KRT85 ; ECTD4; HB5; Hb-5; K85; KRTHB5; hHb5
External IDs	OMIM: 602767 MGI: 1859268 HomoloGene: 37603 GeneCards: KRT85 Gene
Gene ontology Molecular function • structural molecule activity Cellular component • extracellular space • keratin filament Biological process • epidermis development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3891	406219
Ensembl	ENSG00000135443	ENSMUSG00000047641
UniProt	P78386	Q6IMF0
RefSeq (mRNA)	NM_001300810	NM_001003668
RefSeq (protein)	NP_001287739	NP_001003668
Location (UCSC)	Chr 12: 52.36 – 52.37 Mb	Chr 15: 101.43 – 101.44 Mb
PubMed search

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.^[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.^[3]

References

1. Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, Schweizer J (Apr 1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation 61 (3): 187–94. doi:10.1046/j.1432-0436.1997.6130187.x. PMID 9084137.
2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
3. "Entrez Gene: KRT85 keratin 85".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Naeem M, Wajid M, Lee K, et al. (2006). "A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type". J. Med. Genet. 43 (3): 274–9. doi:10.1136/jmg.2005.033381. PMC 2563238. PMID 16525032.
• Tang K, Finley RL, Nie D, Honn KV; Finley (2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry 39 (12): 3185–91. doi:10.1021/bi992664v. PMID 10727209.
• Rogers MA, Winter H, Langbein L, et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". J. Invest. Dermatol. 114 (3): 464–72. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104.
• Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
• Rogers MA, Winter H, Langbein L, et al. (1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5". J. Invest. Dermatol. 107 (4): 633–8. doi:10.1111/1523-1747.ep12584243. PMID 8823373.