KRT86

Keratin 86, type II
Identifiers
Symbols KRT86 ; HB6; Hb1; KRTHB1; KRTHB6; MNX; hHb6
External IDs OMIM: 601928 MGI: 3690448 HomoloGene: 1717 GeneCards: KRT86 Gene
Orthologs
Species Human Mouse
Entrez 3892 16679
Ensembl ENSG00000170442 ENSMUSG00000067614
UniProt O43790 P97861
RefSeq (mRNA) NM_002284 NM_010667
RefSeq (protein) NP_002275 NP_034797
Location (UCSC) Chr 12:
52.25 – 52.31 Mb
Chr 15:
101.47 – 101.48 Mb
PubMed search

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.[3]

References

  1. Winter H, Rogers MA, Langbein L, Stevens HP, Leigh IM, Labreze C, Roul S, Taieb A, Krieg T, Schweizer J (Aug 1997). "Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix". Nat Genet 16 (4): 372–4. doi:10.1038/ng0897-372. PMID 9241275.
  2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  3. 1 2 "Entrez Gene: KRT86 keratin 86".

Further reading

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