MYH8

Myosin, heavy chain 8, skeletal muscle, perinatal
Identifiers
Symbols	MYH8 ; DA7; MyHC-peri; MyHC-pn; gtMHC-F
External IDs	OMIM: 160741 MGI: 1339712 HomoloGene: 68256 GeneCards: MYH8 Gene
Gene ontology Molecular function • microfilament motor activity • calmodulin binding • ATP binding • structural constituent of muscle • ATPase activity • myosin light chain binding • actin filament binding Cellular component • cytoplasm • cytosol • muscle myosin complex • sarcomere • myosin filament Biological process • skeletal muscle contraction • muscle contraction • muscle filament sliding • ATP metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4626	17885
Ensembl	ENSG00000133020	ENSMUSG00000055775
UniProt	P13535	P13542
RefSeq (mRNA)	NM_002472	NM_177369
RefSeq (protein)	NP_002463	NP_796343
Location (UCSC)	Chr 17: 10.39 – 10.42 Mb	Chr 11: 67.28 – 67.31 Mb
PubMed search

Myosin-8 is a protein that in humans is encoded by the MYH8 gene.^[1][2]

References

1. Karsch-Mizrachi I, Feghali R, Shows TB, Leinwand LA (Aug 1990). "Generation of a full-length human perinatal myosin heavy-chain-encoding cDNA". Gene 89 (2): 289–94. doi:10.1016/0378-1119(90)90020-R. PMID 2373371.
2. "Entrez Gene: MYH8 myosin, heavy chain 8, skeletal muscle, perinatal".

Further reading

• Bober E, Buchberger-Seidl A, Braun T, et al. (1990). "Identification of three developmentally controlled isoforms of human myosin heavy chains.". Eur. J. Biochem. 189 (1): 55–65. doi:10.1111/j.1432-1033.1990.tb15459.x. PMID 1691980.
• Bober E, Lyons GE, Braun T, et al. (1991). "The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development.". J. Cell Biol. 113 (6): 1255–65. doi:10.1083/jcb.113.6.1255. PMC 2289041. PMID 2045411.
• Feghali R, Leinwand LA (1989). "Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain.". J. Cell Biol. 108 (5): 1791–7. doi:10.1083/jcb.108.5.1791. PMC 2115547. PMID 2715179.
• Jullian EH, Kelly AM, Pompidou AJ, et al. (1995). "Characterization of a human perinatal myosin heavy-chain transcript.". Eur. J. Biochem. 230 (3): 1001–6. doi:10.1111/j.1432-1033.1995.tb20648.x. PMID 7601129.
• Soussi-Yanicostas N, Whalen RG, Petit C (1993). "Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome.". Hum. Mol. Genet. 2 (5): 563–9. doi:10.1093/hmg/2.5.563. PMID 8518795.
• Veugelers M, Bressan M, McDermott DA, et al. (2004). "Mutation of perinatal myosin heavy chain associated with a Carney complex variant.". N. Engl. J. Med. 351 (5): 460–9. doi:10.1056/NEJMoa040584. PMID 15282353.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Toydemir RM, Chen H, Proud VK, et al. (2007). "Trismus-pseudocamptodactyly syndrome is caused by recurrent mutation of MYH8.". Am. J. Med. Genet. A 140 (22): 2387–93. doi:10.1002/ajmg.a.31495. PMID 17041932.