TMOD3

Tropomodulin 3 (ubiquitous)
Identifiers
Symbols	TMOD3 ; UTMOD
External IDs	OMIM: 605112 MGI: 1355315 HomoloGene: 8727 GeneCards: TMOD3 Gene
Gene ontology Molecular function • actin binding • tropomyosin binding Cellular component • cytoskeleton • striated muscle thin filament • myofibril Biological process • muscle contraction • actin filament organization • myofibril assembly • erythrocyte development • pointed-end actin filament capping • positive regulation of mitotic cell cycle phase transition Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29766	50875
Ensembl	ENSG00000138594	ENSMUSG00000058587
UniProt	Q9NYL9	Q9JHJ0
RefSeq (mRNA)	NM_014547	NM_016963
RefSeq (protein)	NP_055362	NP_058659
Location (UCSC)	Chr 15: 51.83 – 51.95 Mb	Chr 9: 75.5 – 75.56 Mb
PubMed search

Tropomodulin-3 is a protein that in humans is encoded by the TMOD3 gene.^[1][2]

References

1. Cox PR, Zoghbi HY (Apr 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
2. "Entrez Gene: TMOD3 tropomodulin 3 (ubiquitous)".

Further reading

• Weber KL, Fischer RS, Fowler VM (2008). "Tmod3 regulates polarized epithelial cell morphology.". J. Cell. Sci. 120 (Pt 20): 3625–32. doi:10.1242/jcs.011445. PMID 17928307.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Fischer RS, Yarmola EG, Weber KL, et al. (2007). "Tropomodulin 3 binds to actin monomers.". J. Biol. Chem. 281 (47): 36454–65. doi:10.1074/jbc.M606315200. PMID 17012745.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder.". Int. J. Cancer 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Fischer RS, Fritz-Six KL, Fowler VM (2003). "Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility.". J. Cell Biol. 161 (2): 371–80. doi:10.1083/jcb.200209057. PMC 2172920. PMID 12707310.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.