KRT78
| Keratin 78, type II | |||||||||||
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| Identifiers | |||||||||||
| Symbols | KRT78 ; CK-78; K5B; K78; Kb40 | ||||||||||
| External IDs | OMIM: 611159 MGI: 1917529 HomoloGene: 65261 GeneCards: KRT78 Gene | ||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 196374 | 332131 | |||||||||
| Ensembl | ENSG00000170423 | ENSMUSG00000050463 | |||||||||
| UniProt | Q8N1N4 | E9Q0F0 | |||||||||
| RefSeq (mRNA) | NM_001300814 | NM_212487 | |||||||||
| RefSeq (protein) | NP_001287743 | NP_997652 | |||||||||
| Location (UCSC) |
Chr 12: 52.84 – 52.85 Mb |
Chr 15: 101.95 – 101.95 Mb | |||||||||
| PubMed search | |||||||||||
Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.[1][2]
This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified.[2]
References
- ↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
- 1 2 "Entrez Gene: KRT78 keratin 78".
Further reading
- Coulombe PA, Omary MB (2002). "'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments". Curr. Opin. Cell Biol. 14 (1): 110–22. doi:10.1016/S0955-0674(01)00301-5. PMID 11792552.
- Mischke D, Wild G (1987). "Polymorphic keratins in human epidermis". J. Invest. Dermatol. 88 (2): 191–7. doi:10.1111/1523-1747.ep12525329. PMID 2433356.
- Rogers MA, Winter H, Langbein L, et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". J. Invest. Dermatol. 114 (3): 464–72. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104.
- Hesse M, Magin TM, Weber K (2002). "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18". J. Cell. Sci. 114 (Pt 14): 2569–75. PMID 11683385.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Hesse M, Zimek A, Weber K, Magin TM (2004). "Comprehensive analysis of keratin gene clusters in humans and rodents". Eur. J. Cell Biol. 83 (1): 19–26. doi:10.1078/0171-9335-00354. PMID 15085952.
- Rogers MA, Edler L, Winter H, et al. (2005). "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13". J. Invest. Dermatol. 124 (3): 536–44. doi:10.1111/j.0022-202X.2004.23530.x. PMID 15737194.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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