MYH14

Myosin, heavy chain 14, non-muscle
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2YCU​
Identifiers
Symbols	MYH14 ; DFNA4; DFNA4A; FP17425; MHC16; MYH17; NMHC II-C; NMHC-II-C; PNMHH; myosin
External IDs	OMIM: 608568 MGI: 1919210 HomoloGene: 23480 GeneCards: MYH14 Gene
EC number	3.6.4.1
Gene ontology Molecular function • microfilament motor activity • calmodulin binding • ATP binding • actin-dependent ATPase activity • actin filament binding Cellular component • stress fiber • cytosol • brush border • membrane • myosin II complex • axon • growth cone • actomyosin • myelin sheath • extracellular exosome • myosin II filament Biological process • skeletal muscle contraction • small GTPase mediated signal transduction • axon guidance • skeletal muscle tissue development • sensory perception of sound • metabolic process • regulation of cell shape • neuronal action potential • actin filament-based movement • actomyosin structure organization • ephrin receptor signaling pathway • mitochondrion morphogenesis • vocalization behavior Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79784	71960
Ensembl	ENSG00000105357	ENSMUSG00000030739
UniProt	Q7Z406	Q6URW6
RefSeq (mRNA)	NM_001077186	NM_001271538
RefSeq (protein)	NP_001070654	NP_001258467
Location (UCSC)	Chr 19: 50.19 – 50.31 Mb	Chr 7: 44.61 – 44.67 Mb
PubMed search

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.^[1][2][3]

This gene encodes a member of the myosin superfamily. Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.^[3]

References

1. Leal A, Endele S, Stengel C, Huehne K, Loetterle J, Barrantes R, Winterpacht A, Rautenstrauss B (Aug 2003). "A novel myosin heavy chain gene in human chromosome 19q13.3". Gene 312: 165–71. doi:10.1016/S0378-1119(03)00613-9. PMID 12909352.
2. Donaudy F, Snoeckx R, Pfister M, Zenner HP, Blin N, Di Stazio M, Ferrara A, Lanzara C, Ficarella R, Declau F, Pusch CM, Nurnberg P, Melchionda S, Zelante L, Ballana E, Estivill X, Van Camp G, Gasparini P, Savoia A (Mar 2004). "Nonmuscle Myosin Heavy-Chain Gene MYH14 Is Expressed in Cochlea and Mutated in Patients Affected by Autosomal Dominant Hearing Impairment (DFNA4)". Am J Hum Genet 74 (4): 770–6. doi:10.1086/383285. PMC 1181955. PMID 15015131.
3. "Entrez Gene: MYH14 myosin, heavy chain 14".

Further reading

• Chen AH, Ni L, Fukushima K, et al. (1995). "Linkage of a gene for dominant non-syndromic deafness to chromosome 19". Hum. Mol. Genet. 4 (6): 1073–6. doi:10.1093/hmg/4.6.1073. PMID 7655461.
• Shoeman RL, Sachse C, Höner B, et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221–30. PMC 1886840. PMID 8424456.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Desjardins PR, Burkman JM, Shrager JB, et al. (2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi:10.1093/oxfordjournals.molbev.a004093. PMID 11919279.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Golomb E, Ma X, Jana SS, et al. (2004). "Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family". J. Biol. Chem. 279 (4): 2800–8. doi:10.1074/jbc.M309981200. PMID 14594953.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Kim KY, Kovács M, Kawamoto S, et al. (2005). "Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C". J. Biol. Chem. 280 (24): 22769–75. doi:10.1074/jbc.M503488200. PMID 15845534.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

External links

• GeneReviews/NCBI/NIH/UW entry on Deafness and Hereditary Hearing Loss Overview