TMOD4

Tropomodulin 4 (muscle)
Identifiers
Symbols	TMOD4 ; SK-TMOD
External IDs	OMIM: 605834 MGI: 1355285 HomoloGene: 8355 GeneCards: TMOD4 Gene
Gene ontology Molecular function • tropomyosin binding • actin filament binding Cellular component • cytoskeleton • striated muscle thin filament • myofibril Biological process • muscle contraction • actin filament organization • myofibril assembly • pointed-end actin filament capping Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29765	50874
Ensembl	ENSG00000163157	ENSMUSG00000005628
UniProt	Q9NZQ9	Q9JLH8
RefSeq (mRNA)	NM_013353	NM_016712
RefSeq (protein)	NP_037485	NP_057921
Location (UCSC)	Chr 1: 151.17 – 151.18 Mb	Chr 3: 95.12 – 95.13 Mb
PubMed search

Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.^[1][2]

Function

This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.^[3]

References

1. Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
2. Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM (October 1999). "Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle". J. Biol. Chem. 274 (40): 28466–75. doi:10.1074/jbc.274.40.28466. PMID 10497209.
3. "Entrez Gene: TMOD4 , Tropomodulin 4 (muscle)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cox PR, Siddique T, Zoghbi HY (2001). "Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4.". BMC Genomics 2: 7. doi:10.1186/1471-2164-2-7. PMC 59888. PMID 11716785.
• McElhinny AS, Kolmerer B, Fowler VM, et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments.". J. Biol. Chem. 276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID 11016930.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.