TMOD1

Tropomodulin 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4PKG​, 4PKH​, 4PKI​
Identifiers
Symbols	TMOD1 ; D9S57E; ETMOD; TMOD
External IDs	OMIM: 190930 MGI: 98775 HomoloGene: 20701 GeneCards: TMOD1 Gene
Gene ontology Molecular function • tropomyosin binding • actin filament binding Cellular component • cytosol • cytoskeleton • striated muscle thin filament • COP9 signalosome • membrane • myofibril • cortical cytoskeleton Biological process • muscle contraction • actin filament organization • adult locomotory behavior • muscle filament sliding • myofibril assembly • pointed-end actin filament capping • lens fiber cell development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7111	21916
Ensembl	ENSG00000136842	ENSMUSG00000028328
UniProt	P28289	P49813
RefSeq (mRNA)	NM_001166116	NM_021883
RefSeq (protein)	NP_001159588	NP_068683
Location (UCSC)	Chr 9: 97.5 – 97.6 Mb	Chr 4: 46.04 – 46.12 Mb
PubMed search

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.^[1][2][3]

References

1. Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S (Mar 1992). "Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein". J Biol Chem 267 (4): 2616–21. PMID 1370827.
2. Sung LA, Fan Y, Lin CC (Dec 1996). "Gene assignment, expression, and homology of human tropomodulin". Genomics 34 (1): 92–6. doi:10.1006/geno.1996.0245. PMID 8661028.
3. "Entrez Gene: TMOD1 tropomodulin 1".

Further reading

• Ursitti JA, Fowler VM (1994). "Immunolocalization of tropomodulin, tropomyosin and actin in spread human erythrocyte skeletons.". J. Cell. Sci. 107 (6): 1633–9. PMID 7962203.
• Sung LA, Lin JJ (1994). "Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene.". Biochem. Biophys. Res. Commun. 201 (2): 627–34. doi:10.1006/bbrc.1994.1747. PMID 8002995.
• Sussman MA, Bilak M, Kedes L, et al. (1994). "Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions". Exp. Cell Res. 209 (2): 388–91. doi:10.1006/excr.1993.1325. PMID 8262158.
• Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
• Vera C, Sood A, Gao KM, et al. (2000). "Tropomodulin-binding site mapped to residues 7-14 at the N-terminal heptad repeats of tropomyosin isoform 5". Arch. Biochem. Biophys. 378 (1): 16–24. doi:10.1006/abbi.2000.1802. PMID 10871039.
• McElhinny AS, Kolmerer B, Fowler VM, et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments". J. Biol. Chem. 276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID 11016930.
• Chu X, Thompson D, Yee LJ, Sung LA (2001). "Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments". Gene 256 (1–2): 271–81. doi:10.1016/S0378-1119(00)00327-9. PMID 11054557.
• Greenfield NJ, Fowler VM (2002). "Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin". Biophys. J. 82 (5): 2580–91. doi:10.1016/S0006-3495(02)75600-2. PMC 1302047. PMID 11964245.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rho SB, Chun T, Lee SH, et al. (2004). "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture". FEBS Lett. 557 (1–3): 57–63. doi:10.1016/S0014-5793(03)01438-8. PMID 14741341.
• Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vera C, Lao J, Hamelberg D, Sung LA (2006). "Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction". Arch. Biochem. Biophys. 444 (2): 130–8. doi:10.1016/j.abb.2005.10.002. PMID 16297372.
• Kong KY, Kedes L (2006). "Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres". J. Biol. Chem. 281 (14): 9589–99. doi:10.1074/jbc.M512064200. PMID 16434395.