MYH4

Myosin, heavy chain 4, skeletal muscle
PDB rendering based on 1o1g.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1m8q​, 1mvw​, 1o18​, 1o19​, 1o1a​, 1o1b​, 1o1c​, 1o1d​, 1o1e​, 1o1f​, 1o1g​
Identifiers
Symbols	MYH4 ; MYH2B; MyHC-2B; MyHC-IIb
External IDs	OMIM: 160742 MGI: 1339713 HomoloGene: 123880 GeneCards: MYH4 Gene
Gene ontology Molecular function • microfilament motor activity • double-stranded RNA binding • actin binding • calmodulin binding • ATP binding • ATPase activity Cellular component • muscle myosin complex • myofibril • sarcomere • myosin filament Biological process • muscle contraction • response to activity • actin filament-based movement • muscle filament sliding • ATP metabolic process • membrane organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4622	17884
Ensembl	ENSG00000264424	ENSMUSG00000057003
UniProt	Q9Y623	Q5SX39
RefSeq (mRNA)	NM_017533	NM_010855
RefSeq (protein)	NP_060003	NP_034985
Location (UCSC)	Chr 17: 10.44 – 10.47 Mb	Chr 11: 67.24 – 67.26 Mb
PubMed search

Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.^[1]

Function

MYH4 is a myosin.

References

1. Edwards YH, Parkar M, Povey S, West LF, Parrington JM, Solomon E (May 1985). "Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe". Ann. Hum. Genet. 49 (Pt 2): 101–9. doi:10.1111/j.1469-1809.1985.tb01681.x. PMID 3000272.

Further reading

• Sant'ana Pereira JA, Wessels A, Nijtmans L, et al. (1995). "New method for the accurate characterization of single human skeletal muscle fibres demonstrates a relation between mATPase and MyHC expression in pure and hybrid fibre types.". J. Muscle Res. Cell. Motil. 16 (1): 21–34. doi:10.1007/BF00125307. PMID 7751402.
• Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
• Barton PJ, Buckingham ME (1985). "The myosin alkali light chain proteins and their genes.". Biochem. J. 231 (2): 249–61. PMC 1152739. PMID 3904738.
• Horton MJ, Brandon CA, Morris TJ, et al. (2001). "Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres.". Arch. Oral Biol. 46 (11): 1039–50. doi:10.1016/S0003-9969(01)00066-8. PMID 11543711.
• Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
• Larsson L, Moss RL (1993). "Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles.". J. Physiol. (Lond.) 472: 595–614. PMC 1160504. PMID 8145163.
• Li ZH, Spektor A, Varlamova O, Bresnick AR (2003). "Mts1 regulates the assembly of nonmuscle myosin-IIA.". Biochemistry 42 (48): 14258–66. doi:10.1021/bi0354379. PMID 14640694.
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape.". Cell 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
• Ford HL, Silver DL, Kachar B, et al. (1997). "Effect of Mts1 on the structure and activity of nonmuscle myosin II.". Biochemistry 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.
• Soussi-Yanicostas N, Whalen RG, Petit C (1993). "Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome.". Hum. Mol. Genet. 2 (5): 563–9. doi:10.1093/hmg/2.5.563. PMID 8518795.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.