Keratin 13

Keratin 13, type I
Identifiers
Symbols	KRT13 ; CK13; K13; WSN2
External IDs	OMIM: 148065 MGI: 101925 HomoloGene: 40740 GeneCards: KRT13 Gene
Gene ontology Molecular function • structural molecule activity Cellular component • nucleus • keratin filament • intermediate filament cytoskeleton • extracellular exosome Biological process • cytoskeleton organization • response to radiation • tongue morphogenesis • cellular response to retinoic acid Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3860	16663
Ensembl	ENSG00000171401	ENSMUSG00000044041
UniProt	P13646	P08730
RefSeq (mRNA)	NM_002274	NM_010662
RefSeq (protein)	NP_002265	NP_034792
Location (UCSC)	Chr 17: 41.5 – 41.51 Mb	Chr 11: 100.12 – 100.12 Mb
PubMed search

Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene.^[1][2]

Keratin 13 is a type I cytokeratin, it is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.^[3]

K13 is negative in buccal epithelium.

References

1. Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N (October 1992). "Chromosomal mapping of human cytokeratin 13 gene (KRT13)". Genomics 14 (2): 495–7. doi:10.1016/S0888-7543(05)80250-2. PMID 1385306.
2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
3. Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG (December 1995). "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus". Nat. Genet. 11 (4): 453–5. doi:10.1038/ng1295-453. PMID 7493031.

Further reading

• Jacques CM, Pereira AL, Maia V, et al. (2009). "Expression of cytokeratins 10, 13, 14 and 19 in oral lichen planus". J Oral Sci 51 (3): 355–65. doi:10.2334/josnusd.51.355. PMID 19776502.
• Sheng S, Barnett DH, Katzenellenbogen BS (2008). "Differential Estradiol and Selective Estrogen Receptor Modulator (SERM) Regulation of Keratin 13 Gene Expression and its Underlying Mechanism in Breast Cancer Cells". Mol. Cell. Endocrinol. 296 (1–2): 1–9. doi:10.1016/j.mce.2008.09.022. PMC 2654210. PMID 18951949.
• Lu DP, Xing RD, Tatemoto Y, Osaki T (2006). "[Cytokeratin18, 13 and their gene expression in post-operative maxillary cyst linings with metaplastic epithelium]". Zhonghua Kou Qiang Yi Xue Za Zhi 41 (6): 376–9. PMID 16836912.
• Ceratto N, Dobkin C, Carter M, et al. (1997). "Human type I cytokeratin genes are a compact cluster". Cytogenet. Cell Genet. 77 (3–4): 169–74. doi:10.1159/000134566. PMID 9284906.
• Olson GE, Winfrey VP, Blaeuer GL, et al. (2002). "Stage-specific expression of the intermediate filament protein cytokeratin 13 in luminal epithelial cells of secretory phase human endometrium and peri-implantation stage rabbit endometrium". Biol. Reprod. 66 (4): 1006–15. doi:10.1095/biolreprod66.4.1006. PMID 11906920.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Rugg E, Magee G, Wilson N, et al. (1999). "Identification of two novel mutations in keratin 13 as the cause of white sponge naevus". Oral Dis 5 (4): 321–4. doi:10.1111/j.1601-0825.1999.tb00097.x. PMID 10561721.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Shibuya Y, Zhang J, Yokoo S, et al. (2003). "Constitutional mutation of keratin 13 gene in familial white sponge nevus". Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96 (5): 561–5. doi:10.1016/S107921040300372X. PMID 14600690.
• Terrinoni A, Rugg EL, Lane EB, et al. (2001). "A novel mutation in the keratin 13 gene causing oral white sponge nevus". J. Dent. Res. 80 (3): 919–23. doi:10.1177/00220345010800031401. PMID 11379896.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Waseem A, Alam Y, Dogan B, et al. (1998). "Isolation, sequence and expression of the gene encoding human keratin 13". Gene 215 (2): 269–79. doi:10.1016/S0378-1119(98)00297-2. PMID 9714826.
• Raspollini MR, Fambrini M, Marchionni M, et al. (2007). "In situ adenocarcinoma and squamous carcinoma of uterine cervix. Pathological and immunohistochemical analysis with cytokeratin 13". Eur. J. Obstet. Gynecol. Reprod. Biol. 134 (2): 249–53. doi:10.1016/j.ejogrb.2006.07.047. PMID 16949723.
• Sajjan US, Sylvester FA, Forstner JF (2000). "Cable-Piliated Burkholderia cepacia Binds to Cytokeratin 13 of Epithelial Cells". Infect. Immun. 68 (4): 1787–95. doi:10.1128/IAI.68.4.1787-1795.2000. PMC 97349. PMID 10722565.