Prostacyclin receptor

Prostaglandin I2 (prostacyclin) receptor (IP)
Identifiers
Symbols	PTGIR ; IP; PRIPR
External IDs	OMIM: 600022 MGI: 99535 HomoloGene: 7496 IUPHAR: 345 ChEMBL: 1995 GeneCards: PTGIR Gene
Gene ontology Molecular function • G-protein coupled receptor activity • guanyl-nucleotide exchange factor activity Cellular component • cytosol • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-activating G-protein coupled receptor signaling pathway • cell-cell signaling • blood coagulation • negative regulation of platelet-derived growth factor receptor signaling pathway • positive regulation of cAMP biosynthetic process • response to lipopolysaccharide • positive regulation of GTPase activity • positive regulation of cAMP-mediated signaling • negative regulation of smooth muscle cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5739	19222
Ensembl	ENSG00000160013	ENSMUSG00000043017
UniProt	P43119	P43252
RefSeq (mRNA)	NM_000960	NM_008967
RefSeq (protein)	NP_000951	NP_032993
Location (UCSC)	Chr 19: 46.62 – 46.63 Mb	Chr 7: 16.91 – 16.91 Mb
PubMed search

Prostacyclin receptor ( or prostaglandin I₂ receptor, IP₁) is a receptor for prostacyclin, encoded by the PTGIR gene.

It is a member of the G-protein coupled receptor family. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.^[1]

There are actually two receptors for prostacyclin, the other being IP₂.

Transduction

When binding a prostacyclin-molecule, the receptor changes conformation and activates G_s, with its activation of cAMP and increase in protein kinase A (PKA) activity.

In vasodilation

In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. The smooth muscle relaxation leads to vasodilation.^[2]

Gene

The receptor is encoded by the human gene PTGIR.^[1]

See also

• Eicosanoid receptor

References

1. "Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)".
2. Walter F., PhD. Boron (2005). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 479

External links

• "Prostanoid Receptors: IP₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
• Rauvala H, Peng HB (1997). "HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts". Prog. Neurobiol. 52 (2): 127–44. doi:10.1016/S0301-0082(97)00007-5. PMID 9185236.
• Smyth EM, FitzGerald GA (2003). "Human prostacyclin receptor". Vitam. Horm. Vitamins & Hormones 65: 149–65. doi:10.1016/S0083-6729(02)65063-0. ISBN 978-0-12-709865-4. PMID 12481546.
• Boie Y, Rushmore TH, Darmon-Goodwin A, et al. (1994). "Cloning and expression of a cDNA for the human prostanoid IP receptor". J. Biol. Chem. 269 (16): 12173–8. PMID 7512962.
• Katsuyama M, Sugimoto Y, Namba T, et al. (1994). "Cloning and expression of a cDNA for the human prostacyclin receptor". FEBS Lett. 344 (1): 74–8. doi:10.1016/0014-5793(94)00355-6. PMID 7514139.
• Ogawa Y, Tanaka I, Inoue M, et al. (1995). "Structural organization and chromosomal assignment of the human prostacyclin receptor gene". Genomics 27 (1): 142–8. doi:10.1006/geno.1995.1016. PMID 7665161.
• Duncan AM, Anderson LL, Funk CD, et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114.
• Nakagawa O, Tanaka I, Usui T, et al. (1994). "Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system". Circulation 90 (4): 1643–7. doi:10.1161/01.cir.90.4.1643. PMID 7923647.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Sasaki Y, Takahashi T, Tanaka I, et al. (1997). "Expression of prostacyclin receptor in human megakaryocytes". Blood 90 (3): 1039–46. PMID 9242534.
• Fisch A, Tobusch K, Veit K, et al. (1997). "Prostacyclin receptor desensitization is a reversible phenomenon in human platelets". Circulation 96 (3): 756–60. doi:10.1161/01.cir.96.3.756. PMID 9264479.
• Smyth EM, Li WH, FitzGerald GA (1998). "Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c". J. Biol. Chem. 273 (36): 23258–66. doi:10.1074/jbc.273.36.23258. PMID 9722557.
• Kömhoff M, Lesener B, Nakao K, et al. (1999). "Localization of the prostacyclin receptor in human kidney". Kidney Int. 54 (6): 1899–908. doi:10.1046/j.1523-1755.1998.00213.x. PMID 9853255.
• Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi:10.1074/jbc.274.34.23707. PMID 10446129.
• Smyth EM, Austin SC, Reilly MP, FitzGerald GA (2000). "Internalization and sequestration of the human prostacyclin receptor". J. Biol. Chem. 275 (41): 32037–45. doi:10.1074/jbc.M003873200. PMID 10889200.
• Lawler OA, Miggin SM, Kinsella BT (2001). "Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling". J. Biol. Chem. 276 (36): 33596–607. doi:10.1074/jbc.M104434200. PMID 11443126.
• Zhang Z, Austin SC, Smyth EM (2001). "Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction". Mol. Pharmacol. 60 (3): 480–7. PMID 11502878.
• Fortier I, Patry C, Lora M, et al. (2001). "Immunohistochemical localization of the prostacyclin receptor (IP) human bone". Prostaglandins Leukot. Essent. Fatty Acids 65 (2): 79–83. doi:10.1054/plef.2001.0292. PMID 11545623.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.