Prostaglandin F receptor

Prostaglandin F receptor (FP)
Identifiers
Symbols	PTGFR ; FP
External IDs	OMIM: 600563 MGI: 97796 HomoloGene: 741 IUPHAR: 344 ChEMBL: 1987 GeneCards: PTGFR Gene
Gene ontology Molecular function • prostaglandin F receptor activity Cellular component • extracellular region • cytoplasm • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • parturition • positive regulation of cell proliferation • positive regulation of gene expression • response to estradiol • response to lipopolysaccharide • calcium-mediated signaling using intracellular calcium source • negative regulation of apoptotic process • cellular response to prostaglandin D stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5737	19220
Ensembl	ENSG00000122420	ENSMUSG00000028036
UniProt	P43088	P43117
RefSeq (mRNA)	NM_000959	NM_008966
RefSeq (protein)	NP_000950	NP_032992
Location (UCSC)	Chr 1: 78.3 – 78.54 Mb	Chr 3: 151.8 – 151.84 Mb
PubMed search

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F_2α. It is encoded by the gene PTGFR.^[1]

It is a member of the G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG.

Two transcript variants encoding different isoforms have been found for this gene.^[1]

Functions

Main effects of prostaglandin binding to the receptor are:

• uterine contraction
• bronchoconstriction^[2]

Via activation of this receptor, PGF2-alpha mediates luteolysis,^[1] and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.^[3]

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.^[4]

See also

• Eicosanoid receptor

References

1. "Entrez Gene: PTGFR prostaglandin F receptor (FP)".
2. Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003) Page 234
3. Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
4. Sugimoto Y, Yamasaki A, Segi E, et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889.

External links

• "Prostanoid Receptors: FP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Duncan AM, Anderson LL, Funk CD, et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114.
• Lake S, Gullberg H, Wahlqvist J, et al. (1995). "Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor". FEBS Lett. 355 (3): 317–25. doi:10.1016/0014-5793(94)01198-2. PMID 7988697.
• Bastien L, Sawyer N, Grygorczyk R, et al. (1994). "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype". J. Biol. Chem. 269 (16): 11873–7. PMID 8163486.
• Funk CD, Furci L, FitzGerald GA, et al. (1994). "Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype". J. Biol. Chem. 268 (35): 26767–72. PMID 8253813.
• Abramovitz M, Boie Y, Nguyen T, et al. (1994). "Cloning and expression of a cDNA for the human prostanoid FP receptor". J. Biol. Chem. 269 (4): 2632–6. PMID 8300593.
• Sugimoto Y, Yamasaki A, Segi E, et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889.
• Kunapuli P, Lawson JA, Rokach J, FitzGerald GA (1997). "Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha". J. Biol. Chem. 272 (43): 27147–54. doi:10.1074/jbc.272.43.27147. PMID 9341156.
• Betz R, Lagercrantz J, Kedra D, et al. (1999). "Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene". Biochem. Biophys. Res. Commun. 254 (2): 413–6. doi:10.1006/bbrc.1998.9827. PMID 9918852.
• Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR". Mol. Vis. 8: 51–8. PMID 11951086.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Neuschäfer-Rube F, Engemaier E, Koch S, et al. (2003). "Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor". Biochem. J. 371 (Pt 2): 443–9. doi:10.1042/BJ20021429. PMC 1223288. PMID 12519077.
• Zaragoza DB, Wilson R, Eyster K, Olson DM (2004). "Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene". Biochim. Biophys. Acta 1676 (2): 193–202. doi:10.1016/j.bbaexp.2003.11.004. PMID 14746914.
• Sales KJ, Milne SA, Williams AR, et al. (2004). "Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways". J. Clin. Endocrinol. Metab. 89 (2): 986–93. doi:10.1210/jc.2003-031434. PMID 14764825.
• Vielhauer GA, Fujino H, Regan JW (2004). "Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor". Arch. Biochem. Biophys. 421 (2): 175–85. doi:10.1016/j.abb.2003.10.021. PMID 14984197.
• Jin P, Fu GK, Wilson AD, et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
• Sugino N, Karube-Harada A, Taketani T, et al. (2004). "Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation". J. Reprod. Dev. 50 (2): 215–25. doi:10.1262/jrd.50.215. PMID 15118249.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Scott G, Jacobs S, Leopardi S, et al. (2005). "Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation". Exp. Cell Res. 304 (2): 407–16. doi:10.1016/j.yexcr.2004.11.016. PMID 15748887.
• Mandal AK, Ray R, Zhang Z, et al. (2005). "Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators". J. Biol. Chem. 280 (38): 32897–904. doi:10.1074/jbc.M502375200. PMID 16061484.
• Hébert RL, Carmosino M, Saito O, et al. (2005). "Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct.". J. Biol. Chem. 280 (41): 35028–37. doi:10.1074/jbc.M505852200. PMID 16096282.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.