KCNA2

Potassium channel, voltage gated shaker related subfamily A, member 2

PDB rendering based on 1dsx.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1dsx, 1exb, 1qdv, 1qdw, 2a79

Identifiers

Symbols

KCNA2 ; EIEE32; HBK5; HK4; HUKIV; KV1.2; MK2; NGK1; RBK2

External IDs

OMIM: 176262 MGI: 96659 HomoloGene: 21034 IUPHAR: 539 ChEMBL: 2086 GeneCards: KCNA2 Gene

Gene ontology
Molecular function	• voltage-gated potassium channel activity • delayed rectifier potassium channel activity • potassium channel activity • protein binding • outward rectifier potassium channel activity
Cellular component	• endoplasmic reticulum membrane • plasma membrane • integral component of plasma membrane • voltage-gated potassium channel complex • lamellipodium • cell junction • axon • dendrite • lamellipodium membrane • neuronal cell body membrane • presynaptic membrane • perikaryon • axon terminus • juxtaparanode region of axon
Biological process	• potassium ion transport • synaptic transmission • regulation of dopamine secretion • neuronal action potential • sensory perception of pain • optic nerve structural organization • regulation of ion transmembrane transport • regulation of circadian sleep/wake cycle, non-REM sleep • protein homooligomerization • potassium ion transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
110.59 – 110.63 Mb

Chr 3:
107.1 – 107.11 Mb

PubMed search

Potassium voltage-gated channel subfamily A member 2 also known as K_v1.2 is a protein that in humans is encoded by the KCNA2 gene.^[1]^[2]

Function

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.^[2]

Interactions

KCNA2 has been shown to interact with KCNA4,^[3] DLG4,^[4] PTPRA,^[5] KCNAB2,^[3]^[6] RHOA^[7] and Cortactin.^[8]

References

↑ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacological Reviews 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
1 2 "Entrez Gene: KCNA2 potassium voltage-gated channel, shaker-related subfamily, member 2".
1 2 Coleman SK, Newcombe J, Pryke J, Dolly JO (Aug 1999). "Subunit composition of Kv1 channels in human CNS". Journal of Neurochemistry 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084.
↑ Eldstrom J, Doerksen KW, Steele DF, Fedida D (Nov 2002). "N-terminal PDZ-binding domain in Kv1 potassium channels". FEBS Letters 531 (3): 529–37. doi:10.1016/S0014-5793(02)03572-X. PMID 12435606.
↑ Tsai W, Morielli AD, Cachero TG, Peralta EG (Jan 1999). "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity". The EMBO Journal 18 (1): 109–18. doi:10.1093/emboj/18.1.109. PMC 1171107. PMID 9878055.
↑ Nakahira K, Shi G, Rhodes KJ, Trimmer JS (Mar 1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". The Journal of Biological Chemistry 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID 8636142.
↑ Cachero TG, Morielli AD, Peralta EG (Jun 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel". Cell 93 (6): 1077–85. doi:10.1016/S0092-8674(00)81212-X. PMID 9635436.
↑ Hattan D, Nesti E, Cachero TG, Morielli AD (Oct 2002). "Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin". The Journal of Biological Chemistry 277 (41): 38596–606. doi:10.1074/jbc.M205005200. PMID 12151401.

External links

Kv1.2 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNA2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

PDB gallery

1dsx: KV1.2 T1 DOMAIN, RESIDUES 33-119, T46V MUTANT

1exb: STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS

1qdv: N-TERMINAL DOMAIN, VOLTAGE-GATED POTASSIUM CHANNEL KV1.2 RESIDUES 33-131

1qdw: N-TERMINAL DOMAIN, VOLTAGE-GATED POTASSIUM CHANNEL KV1.2 RESIDUES 33-119

2a79: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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KCNA2

Function

Interactions

See also

References

Further reading

External links