Nav1.9

Sodium channel, voltage-gated, type XI, alpha subunit
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SCN11A ; NAV1.9; NaN; SCN12A; SNS-2
External IDs OMIM: 604385 MGI: 1345149 HomoloGene: 8041 IUPHAR: 586 ChEMBL: 5167 GeneCards: SCN11A Gene
Orthologs
Species Human Mouse
Entrez 11280 24046
Ensembl ENSG00000168356 ENSMUSG00000034115
UniProt Q9UI33 Q9R053
RefSeq (mRNA) NM_014139 NM_011887
RefSeq (protein) NP_054858 NP_036017
Location (UCSC) Chr 3:
38.89 – 38.99 Mb		 Chr 9:
119.75 – 119.83 Mb
PubMed search

Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated sodium ion channel protein which in humans is encoded by the SCN11A gene.[1][2]

Function

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[3]

Clinical significance

Mutations in this gene have been associated to loss of pain perception.[4]

References

  1. ↑ Dib-Hajj S, Black JA, Cummins TR, Waxman SG (2002). "NaN/Nav1.9: a sodium channel with unique properties". Trends Neurosci. 25 (5): 253–9. doi:10.1016/S0166-2236(02)02150-1. PMID 11972962.
  2. ↑ Dib-Hajj SD, Tyrrell L, Waxman SG (2002). "Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution". Mol. Neurobiol. 26 (2–3): 235–50. doi:10.1385/MN:26:2-3:235. PMID 12428758.
  3. ↑ "Entrez Gene: Sodium channel, voltage-gated, type XI, alpha subunit".
  4. ↑ Leipold E, Liebmann L, Korenke GC, Heinrich T, Gie?elmann S, Baets J, Ebbinghaus M, Goral RO, St?dberg T, Hennings JC, Bergmann M, Altm?ller J, Thiele H, Wetzel A, N?rnberg P, Timmerman V, De Jonghe P, Blum R, Schaible HG, Weis J, Heinemann SH, H?bner CA, Kurth I (September 2013). "A de novo gain-of-function mutation in SCN11A causes loss of pain perception". Nat. Genet. 45 (11): 1399–404. doi:10.1038/ng.2767. PMID 24036948.

Further reading

  • Delmas P, Coste B (2003). "Na+ channel Nav1.9: in search of a gating mechanism". Trends Neurosci. 26 (2): 55–7. doi:10.1016/S0166-2236(02)00030-9. PMID 12536125. 
  • Blum R, Kafitz KW, Konnerth A (2002). "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9". Nature 419 (6908): 687–93. doi:10.1038/nature01085. PMID 12384689. 
  • Raymond CK, Castle J, Garrett-Engele P, et al. (2004). "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia". J. Biol. Chem. 279 (44): 46234–41. doi:10.1074/jbc.M406387200. PMID 15302875. 
  • Dib-Hajj SD, Tyrrell L, Escayg A, et al. (1999). "Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN". Genomics 59 (3): 309–18. doi:10.1006/geno.1999.5890. PMID 10444332. 
  • Dib-Hajj SD, Tyrrell L, Cummins TR, et al. (1999). "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons". FEBS Lett. 462 (1–2): 117–20. doi:10.1016/S0014-5793(99)01519-7. PMID 10580103. 
  • Jeong SY, Goto J, Hashida H, et al. (2000). "Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A". Biochem. Biophys. Res. Commun. 267 (1): 262–70. doi:10.1006/bbrc.1999.1916. PMID 10623608. 
  • Goldin AL, Barchi RL, Caldwell JH, et al. (2000). "Nomenclature of voltage-gated sodium channels". Neuron 28 (2): 365–8. doi:10.1016/S0896-6273(00)00116-1. PMID 11144347. 
  • Catterall WA, Goldin AL, Waxman SG (2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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