Nav1.2

Sodium channel, voltage gated, type II alpha subunit
PDB rendering based on 1byy.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KAV​, 4JPZ​
Identifiers
Symbols	SCN2A ; BFIC3; BFIS3; BFNIS; EIEE11; HBA; HBSCI; HBSCII; NAC2; Na(v)1.2; Nav1.2; SCN2A1; SCN2A2
External IDs	OMIM: 182390 HomoloGene: 75001 IUPHAR: 579 ChEMBL: 4187 GeneCards: SCN2A Gene
Gene ontology Molecular function • voltage-gated sodium channel activity Cellular component • voltage-gated sodium channel complex • intracellular • plasma membrane • integral component of plasma membrane • intercalated disc • T-tubule • axon • intrinsic component of plasma membrane • node of Ranvier • paranode region of axon • sodium channel complex Biological process • sodium ion transport • intrinsic apoptotic signaling pathway in response to osmotic stress • neuronal action potential • regulation of ion transmembrane transport • sodium ion transmembrane transport • myelination • neuron apoptotic process • membrane depolarization during action potential Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6326	110876
Ensembl	ENSG00000136531	ENSMUSG00000075318
UniProt	Q99250	A2AJZ1
RefSeq (mRNA)	NM_001040142	NM_001099298
RefSeq (protein)	NP_001035232	NP_001092768
Location (UCSC)	Chr 2: 165.24 – 165.39 Mb	Chr 2: 65.62 – 65.77 Mb
PubMed search

Na_vα1.2, also known as the sodium channel, voltage-gated, type II, alpha subunit is a protein that in humans is encoded by the SCN2A gene.^[1] Functional sodium channels contain an ion conductive alpha subunit and one or more regulatory beta subunits. Sodium channels which contain the Na_vα1.2 subunit are called Na_v1.2 channels.

Function

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four domains including 24 transmembrane segments and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[1]

Clinical significance

Mutations in this gene have been implicated in cases of autism,^[2] infantile spasms and bitemporal glucose hypometabolism.^[3]

See also

• Sodium channel

References

1. "Entrez Gene: SCN2A sodium channel, voltage-gated, type II, alpha subunit".
2. Sanders SJ,, Stephan J.; Murtha MT; Gupta AR; Murdoch JR; Raubeson MJ; Willsey AJ; Ercan-Sencicek AG; et al. (2012). "De novo mutations revealed by whole-exome sequencing are strongly associated with autism". Nature. doi:10.1038/nature10945.
3. Sundaram SK, Chugani HT, Tiwari VN, Huq AH (July 2013). "SCN2A Mutation Is Associated With Infantile Spasms and Bitemporal Glucose Hypometabolism". Pediatr. Neurol. 49 (1): 46–9. doi:10.1016/j.pediatrneurol.2013.03.002. PMID 23827426.

Further reading

• Catterall WA, Goldin AL, Waxman SG (2006). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098.
• Lu CM, Han J, Rado TA, Brown GB (1992). "Differential expression of two sodium channel subtypes in human brain.". FEBS Lett. 303 (1): 53–8. doi:10.1016/0014-5793(92)80476-W. PMID 1317301.
• Ahmed CM, Ware DH, Lee SC, et al. (1992). "Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8220–4. doi:10.1073/pnas.89.17.8220. PMC 49889. PMID 1325650.
• Han JA, Lu CM, Brown GB, Rado TA (1991). "Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 335–9. doi:10.1073/pnas.88.2.335. PMC 50805. PMID 1846440.
• Litt M, Luty J, Kwak M, et al. (1989). "Localization of a human brain sodium channel gene (SCN2A) to chromosome 2". Genomics 5 (2): 204–8. doi:10.1016/0888-7543(89)90047-5. PMID 2571571.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Lu CM, Eichelberger JS, Beckman ML, et al. (1999). "Isolation of the 5'-flanking region for human brain sodium channel subtype II alpha-subunit". J. Mol. Neurosci. 11 (3): 179–82. doi:10.1385/JMN:11:3:179. PMID 10344788.
• Baulac S, Gourfinkel-An I, Picard F, et al. (2000). "A Second Locus for Familial Generalized Epilepsy with Febrile Seizures Plus Maps to Chromosome 2q21-q33". Am. J. Hum. Genet. 65 (4): 1078–85. doi:10.1086/302593. PMC 1288241. PMID 10486327.
• Schade SD, Brown GB (2001). "Identifying the promoter region of the human brain sodium channel subtype II gene (SCN2A)". Brain Res. Mol. Brain Res. 81 (1–2): 187–90. doi:10.1016/S0169-328X(00)00145-5. PMID 11000491.
• Kasai N, Fukushima K, Ueki Y, et al. (2001). "Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus". Gene 264 (1): 113–22. doi:10.1016/S0378-1119(00)00594-1. PMID 11245985.
• Malacarne M, Gennaro E, Madia F, et al. (2001). "Benign Familial Infantile Convulsions: Mapping of a Novel Locus on Chromosome 2q24 and Evidence for Genetic Heterogeneity". Am. J. Hum. Genet. 68 (6): 1521–6. doi:10.1086/320596. PMC 1226140. PMID 11326335.
• Sugawara T, Tsurubuchi Y, Agarwala KL, et al. (2001). "A missense mutation of the Na+ channel αII subunit gene Nav1.2 in a patient with febrile and afebrile seizures causes channel dysfunction". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6384–9. doi:10.1073/pnas.111065098. PMC 33477. PMID 11371648.
• Heron SE, Crossland KM, Andermann E, et al. (2002). "Sodium-channel defects in benign familial neonatal-infantile seizures". Lancet 360 (9336): 851–2. doi:10.1016/S0140-6736(02)09968-3. PMID 12243921.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Weiss LA, Escayg A, Kearney JA, et al. (2003). "Sodium channels SCN1A, SCN2A and SCN3A in familial autism". Mol. Psychiatry 8 (2): 186–94. doi:10.1038/sj.mp.4001241. PMID 12610651.
• Yu FH, Westenbroek RE, Silos-Santiago I, et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577–85. PMID 12930796.
• McEwen DP, Meadows LS, Chen C, et al. (2004). "Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin". J. Biol. Chem. 279 (16): 16044–9. doi:10.1074/jbc.M400856200. PMID 14761957.
• Kamiya K, Kaneda M, Sugawara T, et al. (2004). "A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline". J. Neurosci. 24 (11): 2690–8. doi:10.1523/JNEUROSCI.3089-03.2004. PMID 15028761.
• Berkovic SF, Heron SE, Giordano L, et al. (2004). "Benign familial neonatal-infantile seizures: characterization of a new sodium channelopathy". Ann. Neurol. 55 (4): 550–7. doi:10.1002/ana.20029. PMID 15048894.
• Pereira S, Vieira JP, Barroca F, et al. (2004). "Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A". Neurology 63 (1): 191–2. doi:10.1212/01.wnl.0000132844.20654.c1. PMID 15249644.

External links

• SCN2A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.