KCNB2

Potassium channel, voltage gated Shab related subfamily B, member 2
Identifiers
Symbols	KCNB2 ; KV2.2
External IDs	OMIM: 607738 MGI: 99632 HomoloGene: 31263 IUPHAR: 547 GeneCards: KCNB2 Gene
Gene ontology Molecular function • delayed rectifier potassium channel activity • protein heterodimerization activity Cellular component • intracellular • plasma membrane • voltage-gated potassium channel complex • integral component of membrane • dendrite • neuronal cell body membrane • perikaryon Biological process • potassium ion transport • regulation of smooth muscle contraction • synaptic transmission • regulation of ion transmembrane transport • protein homooligomerization • potassium ion transmembrane transport • protein targeting to plasma membrane Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9312	98741
Ensembl	ENSG00000182674	ENSMUSG00000092083
UniProt	Q92953	A6H8H5
RefSeq (mRNA)	NM_004770	NM_001033195
RefSeq (protein)	NP_004761	NP_001091998
Location (UCSC)	Chr 8: 72.54 – 72.94 Mb	Chr 1: 15.29 – 15.72 Mb
PubMed search

Potassium voltage-gated channel subfamily B member 2 is a protein that in humans is encoded by the KCNB2 gene.^[1][2] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[1][2]

References

1. Schmalz F, Kinsella J, Koh SD, Vogalis F, Schneider A, Flynn ER, Kenyon JL, Horowitz B (Jul 1998). "Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles". Am J Physiol 274 (5 Pt 1): G901–11. PMID 9612272.
2. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Nyholt DR, LaForge KS, Kallela M, et al. (2008). "A high-density association screen of 155 ion transport genes for involvement with common migraine". Hum. Mol. Genet. 17 (21): 3318–31. doi:10.1093/hmg/ddn227. PMC 2566523. PMID 18676988.
• Yan L, Figueroa DJ, Austin CP, et al. (2004). "Expression of voltage-gated potassium channels in human and rhesus pancreatic islets". Diabetes 53 (3): 597–607. doi:10.2337/diabetes.53.3.597. PMID 14988243.
• Hugnot JP, Salinas M, Lesage F, et al. (1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". EMBO J. 15 (13): 3322–31. PMC 451895. PMID 8670833.
• Baranzini SE, Wang J, Gibson RA, et al. (2009). "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis". Hum. Mol. Genet. 18 (4): 767–78. doi:10.1093/hmg/ddn388. PMID 19010793.
• Vasan RS, Larson MG, Aragam J, et al. (2007). "Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study". BMC Med. Genet. 8 Suppl 1: S2. doi:10.1186/1471-2350-8-S1-S2. PMC 1995617. PMID 17903301.
• Wu C, Ma MH, Brown KR, et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening". Proteomics 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147.
• Salinas M, de Weille J, Guillemare E, et al. (1997). "Modes of regulation of shab K+ channel activity by the Kv8.1 subunit". J. Biol. Chem. 272 (13): 8774–80. doi:10.1074/jbc.272.13.8774. PMID 9079713.

External links

• Kv2.2 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNB2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)