Cholecystokinin receptor

cholecystokinin A receptor
Identifiers
Symbol	CCKAR
Entrez	886
HUGO	1570
OMIM	118444
RefSeq	NM_000730
UniProt	P32238
Other data
Locus	Chr. 4 p15.2-p15.1

cholecystokinin B receptor
Identifiers
Symbol	CCKBR
Entrez	887
HUGO	1571
OMIM	118445
RefSeq	NM_176875
UniProt	P32239
Other data
Locus	Chr. 11 p15.4

Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin.^[1] There are two different subtypes CCK_A and CCK_B which are ~50% homologous:^[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.

protein	gene	tissue distribution	preferred ligand	function
CCKA (CCK1)	CCKAR	primarily gastrointestinal tract, lesser amounts in the CNS	sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK	stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility
CCKB (CCK2)	CCKBR	primarily CNS, lesser amounts in the gastrointestinal tract	gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides)	regulation of nociception, anxiety, memory and hunger

References

1. Noble F, Wank SA, Crawley JN, Bradwejn J, Seroogy KB, Hamon M, Roques BP (December 1999). "International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors". Pharmacological Reviews 51 (4): 745–81. PMID 10581329.
2. Dufresne M, Seva C, Fourmy D (2006). "Cholecystokinin and gastrin receptors". Physiol. Rev. 86 (3): 805–47. doi:10.1152/physrev.00014.2005. PMID 16816139.

External links

• Cholecystokinin Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)