Eicosanoid receptor

An eicosanoid receptor is an integral membrane protein that detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein-coupled receptors (GPCRs). An example of a non-GPCR receptor that binds eicosanoids is PPAR-γ.^[1]

The following is a list of the known human eicosanoid GPCRs grouped according to the type of eicosanoid ligand that each binds:^[2][3]

Leukotriene

Leukotrienes:

• BLT₁ (Leukotriene B₄ receptor) - LTB4R
• BLT₂ (Leukotriene B₄ receptor 2) - LTB4R2
• CysLT₁ (Cysteinyl leukotriene receptor 1) - CYSLTR1
• CysLT₂ (Cysteinyl leukotriene receptor 2) - CYSLTR2

The recently elucidated CysLT_E, represented by GPR99/OXGR1, may constitute a third CysLTR.^[4]

Lipoxin

Lipoxins:

• LXA4R (Formyl peptide receptor-like 1) - FPRL1

Oxoeicosanoid

Oxoeicosanoid:^[5]

• Oxoeicosanoid (OXE) receptor 1 - OXER1

Prostanoid

Prostanoids:

• PGD₂: DP-(PGD₂) (PGD₂ receptor)
  • DP₁ (PTGDR1) - PTGDR1
  • DP₂ (PTGDR2) - PTGDR2
• PGE₂: EP-(PGE₂) (PGE₂ receptor)
  • EP₁-(PGE₂) (PTGER1) - PTGER1
  • EP₂-(PGE₂) (PTGER2) - PTGER2
  • EP₃-(PGE₂) (PTGER3) - PTGER3
  • EP₄-(PGE₂) (PTGER4) - PTGER4
• PGF_2α: FP-(PGF_2α) (PTGFR) - PTGFR
• PGI₂ (prostacyclin): IP-(PGI₂) (PTGIR) - PTGIR
• TXA₂ (thromboxane): TP-(TXA₂) (TBXA2R) - TBXA2R

References

1. DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). "The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers". Carcinogenesis 19 (1): 49–53. doi:10.1093/carcin/19.1.49. PMID 9472692.
2. Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
3. Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). "International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors". Pharmacol. Rev. 55 (1): 195–227. doi:10.1124/pr.55.1.8. PMID 12615958.
4. Kanaoka Y, Maekawa A, Austen KF (2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". J. Biol. Chem. 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866. PMID 23504326.
5. Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). "International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor". Pharmacol. Rev. 56 (1): 149–57. doi:10.1124/pr.56.1.4. PMID 15001665.

External links

• "Leukotriene Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• "Prostanoid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Eicosanoid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)