IL13RA2

Interleukin 13 receptor, alpha 2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3LB6

Identifiers

Symbols

IL13RA2 ; CD213A2; CT19; IL-13R; IL13BP

External IDs

OMIM: 300130 MGI: 1277954 HomoloGene: 534 GeneCards: IL13RA2 Gene

Gene ontology
Molecular function	• signal transducer activity • cytokine receptor activity
Cellular component	• extracellular space • integral component of membrane
Biological process	• negative regulation of immunoglobulin production • signal transduction • immunoglobulin mediated immune response • cytokine-mediated signaling pathway • negative regulation of mast cell degranulation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
115 – 115.02 Mb

Chr X:
147.38 – 147.43 Mb

PubMed search

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.^[1]

Function

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.^[1]

References

1 2 "Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2".

Andrews AL, Nasir T, Bucchieri F, et al. (1996). "IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts". J. Allergy Clin. Immunol. 118 (4): 858–65. doi:10.1016/j.jaci.2006.06.041. PMID 17030238.
Caput D, Laurent P, Kaghad M, et al. (1996). "Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain". J. Biol. Chem. 271 (28): 16921–6. doi:10.1074/jbc.271.28.16921. PMID 8663118.
Zhang JG, Hilton DJ, Willson TA, et al. (1997). "Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains". J. Biol. Chem. 272 (14): 9474–80. doi:10.1074/jbc.272.14.9474. PMID 9083087.
Gauchat JF, Schlagenhauf E, Feng NP, et al. (1997). "A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor". Eur. J. Immunol. 27 (4): 971–8. doi:10.1002/eji.1830270425. PMID 9130652.
Guo J, Apiou F, Mellerin MP, et al. (1997). "Chromosome mapping and expression of the human interleukin-13 receptor". Genomics 42 (1): 141–5. doi:10.1006/geno.1997.4628. PMID 9177784.
Donaldson DD, Whitters MJ, Fitz LJ, et al. (1998). "The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1". J. Immunol. 161 (5): 2317–24. PMID 9725226.
Osawa M, Miyoshi S, Copeland NG, et al. (2000). "Characterization of the mouse interleukin-13 receptor alpha1 gene". Immunogenetics 51 (11): 974–81. doi:10.1007/s002510000225. PMID 11003391.
Kawakami K, Takeshita F, Puri RK (2001). "Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain". J. Biol. Chem. 276 (27): 25114–20. doi:10.1074/jbc.M100936200. PMID 11352909.
Daines MO, Hershey GK (2002). "A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma". J. Biol. Chem. 277 (12): 10387–93. doi:10.1074/jbc.M108109200. PMID 11786536.
Okano F, Storkus WJ, Chambers WH, et al. (2002). "Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain". Clin. Cancer Res. 8 (9): 2851–5. PMID 12231526.
Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, et al. (2003). "Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein". J. Invest. Dermatol. 119 (5): 1114–20. doi:10.1046/j.1523-1747.2002.19509.x. PMID 12445201.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
David M, Bertoglio J, Pierre J (2003). "TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression". Ann. N. Y. Acad. Sci. 973: 207–9. doi:10.1111/j.1749-6632.2002.tb04633.x. PMID 12485861.
Wu AH, Low WC (2003). "Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter". Neuro-oncology 5 (3): 179–87. doi:10.1215/S1152-8517-02-00051-0. PMC 1920687. PMID 12816724.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Arima K, Sato K, Tanaka G, et al. (2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors". J. Biol. Chem. 280 (26): 24915–22. doi:10.1074/jbc.M502571200. PMID 15870068.
Fichtner-Feigl S, Strober W, Kawakami K, et al. (2006). "IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis". Nat. Med. 12 (1): 99–106. doi:10.1038/nm1332. PMID 16327802.
Daines MO, Tabata Y, Walker BA, et al. (2006). "Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling". J. Immunol. 176 (12): 7495–501. doi:10.4049/jimmunol.176.12.7495. PMID 16751396.
Kioi M, Kawakami M, Shimamura T, et al. (2006). "Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy". Cancer 107 (6): 1407–18. doi:10.1002/cncr.22134. PMID 16902988.
Granel B, Allanore Y, Chevillard C, et al. (2007). "IL13RA2 gene polymorphisms are associated with systemic sclerosis". J. Rheumatol. 33 (10): 2015–9. PMID 16981293.

External links

IL13RA2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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IL13RA2

Function

See also

References

Further reading

External links