CLEC4M

C-type lectin domain family 4, member M
PDB rendering based on 1k9j.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1K9J​, 1SL6​, 1XAR​, 1XPH​, 1Z0Y​, 3JQH​
Identifiers
Symbols	CLEC4M ; CD209L; CD299; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN
External IDs	OMIM: 605872 MGI: 2157947 HomoloGene: 129771 GeneCards: CLEC4M Gene
Gene ontology Molecular function • virus receptor activity • receptor activity • mannose binding • carbohydrate binding • ICAM-3 receptor activity • peptide antigen binding • virion binding • metal ion binding • calcium-dependent protein binding Cellular component • extracellular region • cytoplasm • integral component of plasma membrane • membrane Biological process • adaptive immune response • endocytosis • leukocyte cell-cell adhesion • cell-cell recognition • regulation of gene expression • modulation by virus of host morphology or physiology • virion attachment to host cell • viral genome replication • antigen processing and presentation • regulation of blood coagulation • intracellular signal transduction • innate immune response • viral entry into host cell • peptide antigen transport • intracellular transport of virus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10332	170786
Ensembl	ENSG00000104938	ENSMUSG00000031494
UniProt	Q9H2X3	Q91ZX1
RefSeq (mRNA)	NM_001144904	NM_133238
RefSeq (protein)	NP_001138376	NP_573501
Location (UCSC)	Chr 19: 7.76 – 7.77 Mb	Chr 8: 3.74 – 3.75 Mb
PubMed search

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene.^[1] CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.^[2]

References

1. Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene 228 (1-2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
2. "Entrez Gene: CLEC4M C-type lectin domain family 4, member M".

Further reading

• Baribaud F, Doms RW, Pöhlmann S (2006). "The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?". Expert Opin. Ther. Targets 6 (4): 423–31. doi:10.1517/14728222.6.4.423. PMID 12223058.
• Becker Y (2004). "HIV-1 gp120 binding to dendritic cell receptors mobilize the virus to the lymph nodes, but the induced IL-4 synthesis by FcepsilonRI+ hematopoietic cells damages the adaptive immunity--a review, hypothesis, and implications.". Virus Genes 29 (1): 147–65. doi:10.1023/B:VIRU.0000032797.43537.d3. PMID 15215692.
• Lalor PF, Lai WK, Curbishley SM; et al. (2006). "Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.". World J. Gastroenterol. 12 (34): 5429–39. PMID 17006978.
• Curtis BM, Scharnowske S, Watson AJ (1992). "Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8356–60. doi:10.1073/pnas.89.17.8356. PMC 49917. PMID 1518869.
• Gattegno L, Ramdani A, Jouault T; et al. (1992). "Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1).". AIDS Res. Hum. Retroviruses 8 (1): 27–37. doi:10.1089/aid.1992.8.27. PMID 1736938.
• Soilleux EJ, Barten R, Trowsdale J (2000). "DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13.". J. Immunol. 165 (6): 2937–42. doi:10.4049/jimmunol.165.6.2937. PMID 10975799.
• Pöhlmann S, Soilleux EJ, Baribaud F; et al. (2001). "DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2670–5. doi:10.1073/pnas.051631398. PMC 30196. PMID 11226297.
• Bashirova AA, Geijtenbeek TB, van Duijnhoven GC; et al. (2001). "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.". J. Exp. Med. 193 (6): 671–8. doi:10.1084/jem.193.6.671. PMC 2193415. PMID 11257134.
• Mummidi S, Catano G, Lam L; et al. (2001). "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts.". J. Biol. Chem. 276 (35): 33196–212. doi:10.1074/jbc.M009807200. PMID 11337487.
• Mitchell DA, Fadden AJ, Drickamer K (2001). "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands.". J. Biol. Chem. 276 (31): 28939–45. doi:10.1074/jbc.M104565200. PMID 11384997.
• Feinberg H, Mitchell DA, Drickamer K, Weis WI (2002). "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.". Science 294 (5549): 2163–6. doi:10.1126/science.1066371. PMID 11739956.
• Alvarez CP, Lasala F, Carrillo J; et al. (2002). "C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.". J. Virol. 76 (13): 6841–4. doi:10.1128/JVI.76.13.6841-6844.2002. PMC 136246. PMID 12050398.
• Soilleux EJ, Morris LS, Rushbrook S; et al. (2002). "Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity.". Hum. Pathol. 33 (6): 652–9. doi:10.1053/hupa.2002.124036. PMID 12152166.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lin G, Simmons G, Pöhlmann S; et al. (2003). "Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.". J. Virol. 77 (2): 1337–46. doi:10.1128/JVI.77.2.1337-1346.2003. PMC 140807. PMID 12502850.
• Pöhlmann S, Zhang J, Baribaud F; et al. (2003). "Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.". J. Virol. 77 (7): 4070–80. doi:10.1128/JVI.77.7.4070-4080.2003. PMC 150620. PMID 12634366.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Engering A, van Vliet SJ, Hebeda K; et al. (2004). "Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes.". Am. J. Pathol. 164 (5): 1587–95. doi:10.1016/S0002-9440(10)63717-0. PMC 1615649. PMID 15111305.

External links

• CLEC4M protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• CLEC4M human gene location in the UCSC Genome Browser.
• CLEC4M human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.