FCGR2B

Fc fragment of IgG, low affinity IIb, receptor (CD32)
PDB rendering based on 1fcg.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2FCB​, 3WJJ​, 3WJL​
Identifiers
Symbols	FCGR2B ; CD32; CD32B; FCG2; FCGR2; IGFR2
External IDs	OMIM: 604590 MGI: 95499 HomoloGene: 2974 GeneCards: FCGR2B Gene
Gene ontology Molecular function • protein binding • IgG binding Cellular component • plasma membrane • integral component of membrane Biological process • immune response • signal transduction • viral process • regulation of immune response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2213	14130
Ensembl	ENSG00000072694	ENSMUSG00000026656
UniProt	P31994	P08101
RefSeq (mRNA)	NM_001002273	NM_001077189
RefSeq (protein)	NP_001002273	NP_001070657
Location (UCSC)	Chr 1: 161.58 – 161.68 Mb	Chr 1: 170.96 – 170.98 Mb
PubMed search

Low affinity immunoglobulin gamma Fc region receptor II-b is a protein that, in humans, is encoded by the FCGR2B gene. FCGR2B (CD32B) is a "low affinity" receptor for Immunoglobulin G (IgG). Mutation in the gene in humans leads to a lupus phenotype. ^[1][2] The cytoplasmic part of this receptor contains an immunoreceptor tyrosine-based inhibitory motif, in contrast to the activating isoform, FCGR2A (CD32A).

Function

The inhibitory CD32B is expressed on B cells and myeloid dendritic cells.^[3] Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.^[4][5]

See also

• CD32

References

1. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
2. "Entrez Gene: FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)".
3. Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW (2005). "Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions". J Clin Invest 115 (10): 2914–23. doi:10.1172/JCI24772. PMC 1201664. PMID 16167082. (Free full text)
4. Rankin CT, Veri MC, Gorlatov S, Tuaillon N, Burke S, Huang L, Inzunza HD, Li H, Thomas S, Johnson S, Stavenhagen J, Koenig S, Bonvini E (2006). "CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma". Blood 108 (7): 2384–91. doi:10.1182/blood-2006-05-020602. PMID 16757681. (Free full text)
5. Zhou P, Comenzo RL, Olshen AB, Bonvini E, Koenig S, Maslak PG, Fleisher M, Hoffman J, Jhanwar S, Young JW, Nimer SD, Boruchov AM (2008). "CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody–based therapy". Blood 111 (7): 3403–6. doi:10.1182/blood-2007-11-125526. PMC 2275009. PMID 18216299. (Free full text)

Further reading

• Tsuchiya N, Kyogoku C (2005). "Role of Fc gamma receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: insights from Asia.". Autoimmunity 38 (5): 347–52. doi:10.1080/08916930500123926. PMID 16227149.
• Engelhardt W, Geerds C, Frey J (1990). "Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II.". Eur. J. Immunol. 20 (6): 1367–77. doi:10.1002/eji.1830200624. PMID 2142460.
• Seki T (1989). "Identification of multiple isoforms of the low-affinity human IgG Fc receptor.". Immunogenetics 30 (1): 5–12. doi:10.1007/BF02421463. PMID 2526077.
• Brooks DG, Qiu WQ, Luster AD, Ravetch JV (1989). "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.". J. Exp. Med. 170 (4): 1369–85. doi:10.1084/jem.170.4.1369. PMC 2189488. PMID 2529342.
• Stuart SG, Simister NE, Clarkson SB; et al. (1990). "Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.". EMBO J. 8 (12): 3657–66. PMC 402048. PMID 2531080.
• Stengelin S, Stamenkovic I, Seed B (1988). "Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning.". EMBO J. 7 (4): 1053–9. PMC 454434. PMID 3402431.
• Engelhardt W, Matzke J, Schmidt RE (1995). "Activation-dependent expression of low affinity IgG receptors Fc gamma RII(CD32) and Fc gamma RIII(CD16) in subpopulations of human T lymphocytes.". Immunobiology 192 (5): 297–320. doi:10.1016/s0171-2985(11)80172-5. PMID 7649565.
• D'Ambrosio D, Hippen KL, Minskoff SA; et al. (1995). "Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.". Science 268 (5208): 293–7. doi:10.1126/science.7716523. PMID 7716523.
• Warmerdam PA, van den Herik-Oudijk IE, Parren PW; et al. (1993). "Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses.". Int. Immunol. 5 (3): 239–47. doi:10.1093/intimm/5.3.239. PMID 8466861.
• Bewarder N, Weinrich V, Budde P; et al. (1996). "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.". Mol. Cell. Biol. 16 (9): 4735–43. PMC 231474. PMID 8756631.
• Sandilands GP, MacPherson SA, Burnett ER; et al. (1997). "Differential expression of CD32 isoforms following alloactivation of human T cells.". Immunology 91 (2): 204–11. doi:10.1046/j.1365-2567.1997.00241.x. PMC 1363848. PMID 9227318.
• De SK, Venkateshan CN, Seth P; et al. (1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines.". Blood 91 (6): 2108–17. PMID 9490697.
• Metes D, Ernst LK, Chambers WH; et al. (1998). "Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.". Blood 91 (7): 2369–80. PMID 9516136.
• Sondermann P, Huber R, Jacob U (1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577.
• Muraille E, Bruhns P, Pesesse X; et al. (2000). "The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling.". Immunol. Lett. 72 (1): 7–15. doi:10.1016/S0165-2478(00)00162-0. PMID 10789675.
• Pricop L, Redecha P, Teillaud JL; et al. (2001). "Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines.". J. Immunol. 166 (1): 531–7. doi:10.4049/jimmunol.166.1.531. PMID 11123333.
• Lyden TW, Robinson JM, Tridandapani S; et al. (2001). "The Fc receptor for IgG expressed in the villus endothelium of human placenta is Fc gamma RIIb2.". J. Immunol. 166 (6): 3882–9. doi:10.4049/jimmunol.166.6.3882. PMID 11238632.
• Bharadwaj D, Mold C, Markham E, Du Clos TW (2001). "Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis.". J. Immunol. 166 (11): 6735–41. doi:10.4049/jimmunol.166.11.6735. PMID 11359830.
• Jessup CF, Ridings J, Ho A; et al. (2001). "The Fc receptor for IgG (Fc gamma RII; CD32) on human neonatal B lymphocytes.". Hum. Immunol. 62 (7): 679–85. doi:10.1016/S0198-8859(01)00257-9. PMID 11423173.

External links

• FCGR2B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.