ENTPD1

Ectonucleoside triphosphate diphosphohydrolase 1
Identifiers
Symbols ENTPD1 ; ATPDase; CD39; NTPDase-1; SPG64
External IDs OMIM: 601752 MGI: 102805 HomoloGene: 20423 ChEMBL: 5722 GeneCards: ENTPD1 Gene
EC number 3.6.1.5
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 953 12495
Ensembl ENSG00000138185 ENSMUSG00000048120
UniProt P49961 P55772
RefSeq (mRNA) NM_001098175 NM_001304721
RefSeq (protein) NP_001091645 NP_001291650
Location (UCSC) Chr 10:
95.71 – 95.88 Mb		 Chr 19:
40.61 – 40.74 Mb
PubMed search

Ectonucleoside triphosphate diphosphohydrolase-1 (gene: ENTPD1; protein: NTPDase1) also known as CD39 (Cluster of Differentiation 39), is a typical cell surface-located enzymes with an extracellularly facing catalytic site.[1][2][3] NTPDase1 is an ectonucleotidase that catalyse the hydrolysis of γ- and β-phosphate residues of triphospho- and diphosphonucleosides to the monophosphonucleoside derivative.[4][5] For example, NTPDase1 hydrolyzes P2 receptor ligands, namely ATP, ADP, UTP and UDP with similar efficacy.[6] NTPDase1 can therefore affect P2 receptor activation and functions.[7]

See also

References

  1. ↑ "Entrez Gene: ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1".
  2. ↑ Sévigny J, Levesque FP, Grondin G, Beaudoin AR (Feb 1997). "Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques". Biochimica et Biophysica Acta 1334 (1): 73–88. PMID 9042368.
  3. ↑ Kaczmarek E, Koziak K, Sévigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC (Dec 1996). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". The Journal of Biological Chemistry 271 (51): 33116–22. PMID 8955160.
  4. ↑ Robson SC, Sévigny J, Zimmermann H (Jun 2006). "The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance". Purinergic Signalling 2 (2): 409–30. doi:10.1007/s11302-006-9003-5. PMC 2254478. PMID 18404480.
  5. ↑ Yegutkin GG (May 2008). "Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade". Biochimica et Biophysica Acta 1783 (5): 673–94. doi:10.1016/j.bbamcr.2008.01.024. PMID 18302942.
  6. ↑ Kukulski F, Lévesque SA, Lavoie EG, Lecka J, Bigonnesse F, Knowles AF, Robson SC, Kirley TL, Sévigny J (Jun 2005). "Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8". Purinergic Signalling 1 (2): 193–204. doi:10.1007/s11302-005-6217-x. PMC 2096530. PMID 18404504.
  7. ↑ Kukulski F, Lévesque SA, Sévigny J (2011-01-01). "Impact of ectoenzymes on p2 and p1 receptor signaling". Advances in Pharmacology 61: 263–99. doi:10.1016/B978-0-12-385526-8.00009-6. PMID 21586362.

Further reading

  • Maliszewski CR, Delespesse GJ, Schoenborn MA, Armitage RJ, Fanslow WC, Nakajima T, Baker E, Sutherland GR, Poindexter K, Birks C (Oct 1994). "The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization". Journal of Immunology 153 (8): 3574–83. PMID 7930580. 
  • Christoforidis S, Papamarcaki T, Galaris D, Kellner R, Tsolas O (Nov 1995). "Purification and properties of human placental ATP diphosphohydrolase". European Journal of Biochemistry / FEBS 234 (1): 66–74. doi:10.1111/j.1432-1033.1995.066_c.x. PMID 8529670. 
  • Wang TF, Guidotti G (Apr 1996). "CD39 is an ecto-(Ca2+,Mg2+)-apyrase". The Journal of Biological Chemistry 271 (17): 9898–901. doi:10.1074/jbc.271.17.9898. PMID 8626624. 
  • Kaczmarek E, Koziak K, Sévigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC (Dec 1996). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". The Journal of Biological Chemistry 271 (51): 33116–22. doi:10.1074/jbc.271.51.33116. PMID 8955160. 
  • Robson SC, Kaczmarek E, Siegel JB, Candinas D, Koziak K, Millan M, Hancock WW, Bach FH (Jan 1997). "Loss of ATP diphosphohydrolase activity with endothelial cell activation". The Journal of Experimental Medicine 185 (1): 153–63. doi:10.1084/jem.185.1.153. PMC 2196106. PMID 8996251. 
  • Gray IC, Fallowfield J, Ford S, Nobile C, Volpi EV, Spurr NK (Jul 1997). "An integrated physical and genetic map spanning chromosome band 10q24". Genomics 43 (1): 85–8. doi:10.1006/geno.1997.4809. PMID 9226376. 
  • Makita K, Shimoyama T, Sakurai Y, Yagi H, Matsumoto M, Narita N, Sakamoto Y, Saito S, Ikeda Y, Suzuki M, Titani K, Fujimura Y (Oct 1998). "Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation". International Journal of Hematology 68 (3): 297–310. doi:10.1016/S0925-5710(98)00080-2. PMID 9846014. 
  • Matsumoto M, Sakurai Y, Kokubo T, Yagi H, Makita K, Matsui T, Titani K, Fujimura Y, Narita N (Jun 1999). "The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II". FEBS Letters 453 (3): 335–40. doi:10.1016/S0014-5793(99)00751-6. PMID 10405171. 
  • Kittel A, Kaczmarek E, Sevigny J, Lengyel K, Csizmadia E, Robson SC (Sep 1999). "CD39 as a caveolar-associated ectonucleotidase". Biochemical and Biophysical Research Communications 262 (3): 596–9. doi:10.1006/bbrc.1999.1254. PMID 10471369. 
  • Koziak K, Kaczmarek E, Kittel A, Sévigny J, Blusztajn JK, Schulte Am Esch J, Imai M, Guckelberger O, Goepfert C, Qawi I, Robson SC (Jan 2000). "Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae". The Journal of Biological Chemistry 275 (3): 2057–62. doi:10.1074/jbc.275.3.2057. PMID 10636909. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. 
  • Goepfert C, Imai M, Brouard S, Csizmadia E, Kaczmarek E, Robson SC (Jul 2000). "CD39 modulates endothelial cell activation and apoptosis". Molecular Medicine 6 (7): 591–603. PMC 1949966. PMID 10997340. 
  • Kittel A, Garrido M, Varga G (Apr 2002). "Localization of NTPDase1/CD39 in normal and transformed human pancreas". The Journal of Histochemistry and Cytochemistry 50 (4): 549–56. doi:10.1177/002215540205000412. PMID 11897808. 
  • Kaneider NC, Egger P, Dunzendorfer S, Noris P, Balduini CL, Gritti D, Ricevuti G, Wiedermann CJ (Jun 2002). "Reversal of thrombin-induced deactivation of CD39/ATPDase in endothelial cells by HMG-CoA reductase inhibition: effects on Rho-GTPase and adenosine nucleotide metabolism". Arteriosclerosis, Thrombosis, and Vascular Biology 22 (6): 894–900. doi:10.1161/01.ATV.0000018305.95943.F7. PMID 12067895. 
  • Drosopoulos JH (Oct 2002). "Roles of Asp54 and Asp213 in Ca2+ utilization by soluble human CD39/ecto-nucleotidase". Archives of Biochemistry and Biophysics 406 (1): 85–95. doi:10.1016/S0003-9861(02)00414-9. PMID 12234494. 
  • Krötz F, Sohn HY, Keller M, Gloe T, Bolz SS, Becker BF, Pohl U (Dec 2002). "Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase". Arteriosclerosis, Thrombosis, and Vascular Biology 22 (12): 2003–9. doi:10.1161/01.ATV.0000043454.08172.51. PMID 12482826. 
  • Rossatto ER, da Silva LB, Pereira GS, Bonan CD, Battastini AM, Ribeiro JP, Sarkis JJ (Feb 2003). "ATP diphosphohydrolase in human platelets from patients with coronary arteries heart disease". Platelets 14 (1): 47–52. doi:10.1080/0953710021000062923. PMID 12623446. 
  • Sørensen CE, Amstrup J, Rasmussen HN, Ankorina-Stark I, Novak I (Sep 2003). "Rat pancreas secretes particulate ecto-nucleotidase CD39". The Journal of Physiology 551 (Pt 3): 881–92. doi:10.1113/jphysiol.2003.049411. PMC 2343304. PMID 12832497. 
  • Sévigny J, Sundberg C, Braun N, Guckelberger O, Csizmadia E, Qawi I, Imai M, Zimmermann H, Robson SC (Apr 2002). "Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation". Blood 99 (8): 2801–9. PMID 11929769. 

External links


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