CEACAM5

Carcinoembryonic antigen-related cell adhesion molecule 5

PDB rendering based on 1e07.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1E07, 2QSQ, 2QST, 2VER

Identifiers

Symbols

CEACAM5 ; CD66e; CEA

External IDs

OMIM: 114890 HomoloGene: 128801 GeneCards: CEACAM5 Gene

Gene ontology
Molecular function	• GPI anchor binding • identical protein binding • protein homodimerization activity
Cellular component	• integral component of plasma membrane • basolateral plasma membrane • anchored component of membrane • extracellular exosome • integral component of external side of plasma membrane
Biological process	• negative regulation of myotube differentiation • homotypic cell-cell adhesion • negative regulation of apoptotic process • negative regulation of anoikis
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_001291484

n/a

RefSeq (protein)

NP_001278413

n/a

Location (UCSC)

Chr 19:
41.58 – 41.73 Mb

n/a

PubMed search

n/a

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a human gene.^[1]

References

↑ "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5".

Willcocks TC, Craig IW (1991). "Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region.". Genomics 8 (3): 492–500. doi:10.1016/0888-7543(90)90036-T. PMID 2286372.
Barnett T, Zimmermann W (1990). "Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family.". Tumour Biol. 11 (1–2): 59–63. doi:10.1159/000217643. PMID 2309067.
Schrewe H, Thompson J, Bona M; et al. (1990). "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression". Mol. Cell. Biol. 10 (6): 2738–48. PMC 360634. PMID 2342461.
Kamarck ME, Elting JJ, Hart JT; et al. (1987). "Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11". Proc. Natl. Acad. Sci. U.S.A. 84 (15): 5350–4. doi:10.1073/pnas.84.15.5350. PMC 298853. PMID 2955415.
Zimmermann W, Ortlieb B, Friedrich R, von Kleist S (1987). "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2960–4. doi:10.1073/pnas.84.9.2960. PMC 304780. PMID 3033671.
Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (1989). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics 3 (1): 59–66. doi:10.1016/0888-7543(88)90160-7. PMID 3220478.
Zimmermann W, Weber B, Ortlieb B; et al. (1988). "Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors". Cancer Res. 48 (9): 2550–4. PMID 3356015.
Beauchemin N, Benchimol S, Cournoyer D; et al. (1987). "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen". Mol. Cell. Biol. 7 (9): 3221–30. PMC 367958. PMID 3670312.
Oikawa S, Nakazato H, Kosaki G (1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". Biochem. Biophys. Res. Commun. 142 (2): 511–8. doi:10.1016/0006-291X(87)90304-4. PMID 3814146.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hart SP, Ross JA, Ross K; et al. (2000). "Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes". Cell Death Differ. 7 (5): 493–503. doi:10.1038/sj.cdd.4400680. PMID 10800083.
Guignot J, Peiffer I, Bernet-Camard MF; et al. (2000). "Recruitment of CD55 and CD66e Brush Border-Associated Glycosylphosphatidylinositol-Anchored Proteins by Members of the Afa/Dr Diffusely Adhering Family of Escherichia coli That Infect the Human Polarized Intestinal Caco-2/TC7 Cells". Infect. Immun. 68 (6): 3554–63. doi:10.1128/IAI.68.6.3554-3563.2000. PMC 97642. PMID 10816511.
Boehm MK, Perkins SJ (2000). "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23". FEBS Lett. 475 (1): 11–6. doi:10.1016/S0014-5793(00)01612-4. PMID 10854848.
Screaton RA, DeMarte L, Dráber P, Stanners CP (2000). "The Specificity for the Differentiation Blocking Activity of Carcinoembryonic Antigen Resides in Its Glycophosphatidyl-Inositol Anchor". J. Cell Biol. 150 (3): 613–26. doi:10.1083/jcb.150.3.613. PMC 2175204. PMID 10931872.
Bajenova OV, Zimmer R, Stolper E; et al. (2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". J. Biol. Chem. 276 (33): 31067–73. doi:10.1074/jbc.M104093200. PMID 11406629.
Wirth T, Soeth E, Czubayko F, Juhl H (2002). "Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth". Clin. Exp. Metastasis 19 (2): 155–60. doi:10.1023/A:1014566127493. PMID 11964079.
Louhimo J, Carpelan-Holmström M, Alfthan H; et al. (2002). "Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer". Int. J. Cancer 101 (6): 545–8. doi:10.1002/ijc.90009. PMID 12237895.
Hampton R, Walker M, Marshall J, Juhl H (2002). "Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells". Oncogene 21 (51): 7817–23. doi:10.1038/sj.onc.1205906. PMID 12420218.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

PDB gallery

External links

CEACAM5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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CEACAM5

See also

References

Further reading

External links