KLRD1

Killer cell lectin-like receptor subfamily D, member 1

PDB rendering based on 1b6e.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KLRD1 ; CD94
External IDs OMIM: 602894 MGI: 1196275 HomoloGene: 1705 GeneCards: KLRD1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3824 16643
Ensembl ENSG00000134539 ENSMUSG00000030165
UniProt Q13241 O54707
RefSeq (mRNA) NM_001114396 NM_010654
RefSeq (protein) NP_001107868 NP_034784
Location (UCSC) Chr 12:
10.23 – 10.33 Mb		 Chr 6:
129.59 – 129.6 Mb
PubMed search

CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene.[1]

The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Function

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.[1]

Interactions

KLRD1 has been shown to interact with KLRC2.[2][3]

See also

References

  1. 1 2 "Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1".
  2. ↑ Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology 157 (11): 4741–5. PMID 8943374.
  3. ↑ Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637.

Further reading

  • Chang C, Rodríguez A, Carretero M, López-Botet M, Phillips JH, Lanier LL (Sep 1995). "Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily". European Journal of Immunology 25 (9): 2433–7. doi:10.1002/eji.1830250904. PMID 7589107. 
  • Moretta A, Vitale M, Sivori S, Bottino C, Morelli L, Augugliaro R, Barbaresi M, Pende D, Ciccone E, Lopez-Botet M, Moretta L (Aug 1994). "Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles". The Journal of Experimental Medicine 180 (2): 545–55. doi:10.1084/jem.180.2.545. PMC 2191622. PMID 8046333. 
  • Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL (Aug 1996). "CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes". Immunity 5 (2): 163–72. doi:10.1016/S1074-7613(00)80492-6. PMID 8769479. 
  • Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology 157 (11): 4741–5. PMID 8943374. 
  • Brooks AG, Posch PE, Scorzelli CJ, Borrego F, Coligan JE (Feb 1997). "NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor". The Journal of Experimental Medicine 185 (4): 795–800. doi:10.1084/jem.185.4.795. PMC 2196137. PMID 9034158. 
  • Mandelboim O, Pazmany L, Davis DM, Valés-Gómez M, Reyburn HT, Rybalov B, Strominger JL (Dec 1997). "Multiple receptors for HLA-G on human natural killer cells". Proceedings of the National Academy of Sciences of the United States of America 94 (26): 14666–70. doi:10.1073/pnas.94.26.14666. PMC 25087. PMID 9405670. 
  • Rodríguez A, Carretero M, Glienke J, Bellón T, Ramírez A, Lehrach H, Francis F, López-Botet M (Mar 1998). "Structure of the human CD94 C-type lectin gene". Immunogenetics 47 (4): 305–9. doi:10.1007/s002510050362. PMID 9472066. 
  • Le Dréan E, Vély F, Olcese L, Cambiaggi A, Guia S, Krystal G, Gervois N, Moretta A, Jotereau F, Vivier E (Jan 1998). "Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases". European Journal of Immunology 28 (1): 264–76. doi:10.1002/(SICI)1521-4141(199801)28:01<264::AID-IMMU264>3.0.CO;2-O. PMID 9485206. 
  • Braud VM, Allan DS, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ (Feb 1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature 391 (6669): 795–9. doi:10.1038/35869. PMID 9486650. 
  • Plougastel B, Trowsdale J (Apr 1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes". Genomics 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306. 
  • Furukawa H, Yabe T, Watanabe K, Miyamoto R, Akaza T, Tadokoro K, Tohma S, Inoue T, Yamamoto K, Juji T (Jun 1998). "An alternatively spliced form of the human CD94 gene". Immunogenetics 48 (1): 87–8. doi:10.1007/s002510050407. PMID 9601951. 
  • Lanier LL, Corliss B, Wu J, Phillips JH (Jun 1998). "Association of DAP12 with activating CD94/NKG2C NK cell receptors". Immunity 8 (6): 693–701. doi:10.1016/S1074-7613(00)80574-9. PMID 9655483. 
  • Vance RE, Kraft JR, Altman JD, Jensen PE, Raulet DH (Nov 1998). "Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b)". The Journal of Experimental Medicine 188 (10): 1841–8. doi:10.1084/jem.188.10.1841. PMC 2212405. PMID 9815261. 
  • Brooks AG, Borrego F, Posch PE, Patamawenu A, Scorzelli CJ, Ulbrecht M, Weiss EH, Coligan JE (Jan 1999). "Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells". Journal of Immunology 162 (1): 305–13. PMID 9886400. 
  • Boyington JC, Riaz AN, Patamawenu A, Coligan JE, Brooks AG, Sun PD (Jan 1999). "Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors". Immunity 10 (1): 75–82. doi:10.1016/S1074-7613(00)80008-4. PMID 10023772. 
  • Bellón T, Heredia AB, Llano M, Minguela A, Rodriguez A, López-Botet M, Aparicio P (Apr 1999). "Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer". Journal of Immunology 162 (7): 3996–4002. PMID 10201920. 
  • Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637. 
  • Romero P, Ortega C, Palma A, Molina IJ, Peña J, Santamaría M (Aug 2001). "Expression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3-mediated stimulation". Journal of Leukocyte Biology 70 (2): 219–24. PMID 11493613. 
  • Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham P (Jan 2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes". Journal of Immunology 168 (1): 240–52. doi:10.4049/jimmunol.168.1.240. PMID 11751968. 
  • Terrazzano G, Zanzi D, Palomba C, Carbone E, Grimaldi S, Pisanti S, Fontana S, Zappacosta S, Ruggiero G (Aug 2002). "Differential involvement of CD40, CD80, and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors". Journal of Leukocyte Biology 72 (2): 305–11. PMID 12149421. 

External links


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