CD226

CD226 molecule
Identifiers
Symbols	CD226 ; DNAM-1; DNAM1; PTA1; TLiSA1
External IDs	OMIM: 605397 MGI: 3039602 HomoloGene: 4787 GeneCards: CD226 Gene
Gene ontology Molecular function • receptor activity • integrin binding • protein binding • protein kinase binding • protein homodimerization activity • cell adhesion molecule binding Cellular component • plasma membrane • integral component of plasma membrane • cell-cell adherens junction • external side of plasma membrane • cell surface • membrane raft Biological process • cytokine production • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target • positive regulation of immunoglobulin mediated immune response • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • signal transduction • cell recognition • positive regulation of mast cell activation • positive regulation of natural killer cell mediated cytotoxicity • regulation of immune response • positive regulation of Fc receptor mediated stimulatory signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10666	225825
Ensembl	ENSG00000150637	ENSMUSG00000034028
UniProt	Q15762	Q8K4F0
RefSeq (mRNA)	NM_001303618	NM_001039148
RefSeq (protein)	NP_001290547	NP_001034238
Location (UCSC)	Chr 18: 69.83 – 69.96 Mb	Chr 18: 89.2 – 89.27 Mb
PubMed search

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')^[1] or DNAM-1 (DNAX Accessory Molecule-1)^[1] is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.^[2]

Structure and function

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,^[3][4] and cross-linking CD226 with antibodies causes cellular activation.^[2]

See also

• Cluster of differentiation
• Nectin

References

1. Fuchs, Anja; Colonna, M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
2. "Entrez Gene: CD226 CD226 molecule".
3. Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". J. Exp. Med. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096.
4. Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". Int. Immunol. 16 (4): 533–8. doi:10.1093/intimm/dxh059. PMID 15039383.

Further reading

• Shibuya A, Campbell D, Hannum C; et al. (1996). "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.". Immunity 4 (6): 573–81. doi:10.1016/S1074-7613(00)70060-4. PMID 8673704.
• Shibuya K, Lanier LL, Phillips JH; et al. (2000). "Physical and functional association of LFA-1 with DNAM-1 adhesion molecule.". Immunity 11 (5): 615–23. doi:10.1016/S1074-7613(00)80136-3. PMID 10591186.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kojima H, Kanada H, Shimizu S; et al. (2003). "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells.". J. Biol. Chem. 278 (38): 36748–53. doi:10.1074/jbc.M300702200. PMID 12847109.
• Shibuya K, Shirakawa J, Kameyama T; et al. (2004). "CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation.". J. Exp. Med. 198 (12): 1829–39. doi:10.1084/jem.20030958. PMC 2194159. PMID 14676297.
• Reymond N, Imbert AM, Devilard E; et al. (2004). "DNAM-1 and PVR regulate monocyte migration through endothelial junctions.". J. Exp. Med. 199 (10): 1331–41. doi:10.1084/jem.20032206. PMC 2211807. PMID 15136589.
• Ralston KJ, Hird SL, Zhang X; et al. (2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large.". J. Biol. Chem. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pende D, Spaggiari GM, Marcenaro S; et al. (2005). "Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).". Blood 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144.
• Pende D, Bottino C, Castriconi R; et al. (2005). "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.". Mol. Immunol. 42 (4): 463–9. doi:10.1016/j.molimm.2004.07.028. PMID 15607800.
• Tao D, Shangwu L, Qun W; et al. (2005). "CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus.". J. Immunol. 174 (3): 1281–90. doi:10.4049/jimmunol.174.3.1281. PMID 15661884.
• Ma D, Sun Y, Lin D; et al. (2005). "CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization.". Eur. J. Haematol. 74 (3): 228–40. doi:10.1111/j.1600-0609.2004.00345.x. PMID 15693793.
• Storojeva I, Boulay JL, Ballabeni P; et al. (2005). "Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer.". Oncology 68 (2–3): 246–55. doi:10.1159/000086781. PMID 16015041.
• Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (2006). "Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process". J. Biol. Chem. 281 (37): 27190–6. doi:10.1074/jbc.M602359200. PMID 16831868.
• Jian JL, Zhu CS, Xu ZW; et al. (2006). "Identification and characterization of the CD226 gene promoter". J. Biol. Chem. 281 (39): 28731–6. doi:10.1074/jbc.M601786200. PMID 16887814.
• Ye X, Zhang Z, Jiang Y; et al. (2006). "Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients". Viral Immunol. 19 (3): 576–81. doi:10.1089/vim.2006.19.576. PMID 16987076.
• El-Sherbiny YM, Meade JL, Holmes TD; et al. (2007). "The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells". Cancer Res. 67 (18): 8444–9. doi:10.1158/0008-5472.CAN-06-4230. PMID 17875681.

External links

• CD226 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.