FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

PDB rendering based on 1e4j.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3AY4, 3SGJ, 3SGK, 3WN5

Identifiers

Symbols

FCGR3A ; CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20

External IDs

OMIM: 146740 MGI: 2179523 HomoloGene: 477 GeneCards: FCGR3A Gene

Gene ontology
Molecular function	• IgG binding
Cellular component	• plasma membrane • external side of plasma membrane • integral component of membrane • extracellular exosome
Biological process	• immune response • Fc-gamma receptor signaling pathway involved in phagocytosis • innate immune response • regulation of immune response
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
161.54 – 161.55 Mb

Chr 1:
171.02 – 171.03 Mb

PubMed search

Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene.^[1]^[2] It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.

References

↑ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
↑ "Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)".

Anderson P, Caligiuri M, O'Brien C, et al. (1990). "Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2274–8. doi:10.1073/pnas.87.6.2274. PMC 53669. PMID 2138330.
Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23". Immunogenetics 32 (3): 183–6. doi:10.1007/BF02114971. PMID 2146219.
Ory PA, Clark MR, Kwoh EE, et al. (1989). "Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils". J. Clin. Invest. 84 (5): 1688–91. doi:10.1172/JCI114350. PMC 304039. PMID 2478590.
Peltz GA, Grundy HO, Lebo RV, et al. (1989). "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 1013–7. doi:10.1073/pnas.86.3.1013. PMC 286611. PMID 2521732.
Scallon BJ, Scigliano E, Freedman VH, et al. (1989). "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 5079–83. doi:10.1073/pnas.86.13.5079. PMC 297560. PMID 2525780.
Ravetch JV, Perussia B (1989). "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions". J. Exp. Med. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMC 2189395. PMID 2526846.
Simmons D, Seed B (1988). "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein". Nature 333 (6173): 568–70. doi:10.1038/333568a0. PMID 2967436.
Indik ZK, Hunter S, Huang MM, et al. (1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Exp. Hematol. 22 (7): 599–606. PMID 7516890.
Detmers PA, Zhou D, Powell D, et al. (1995). "Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase". J. Immunol. 155 (4): 2085–95. PMID 7543538.
Morcos M, Hänsch GM, Schönermark M, et al. (1995). "Human glomerular mesangial cells express CD16 and may be stimulated via this receptor". Kidney Int. 46 (6): 1627–34. doi:10.1038/ki.1994.462. PMID 7700021.
Schumann G, Dasgupta JD (1995). "Specificity of signal transduction through CD16, TCR-CD3 and BCR receptor chains containing the tyrosine-associated activation motif". Int. Immunol. 6 (9): 1383–92. doi:10.1093/intimm/6.9.1383. PMID 7819147.
Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (1995). "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions". J. Biol. Chem. 270 (3): 1350–61. doi:10.1074/jbc.270.3.1350. PMID 7836402.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Altin JG, Pagler EB, Kinnear BF, Warren HS (1994). "Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells". Immunol. Cell Biol. 72 (1): 87–96. doi:10.1038/icb.1994.13. PMID 8157290.
Pignata C, Prasad KV, Robertson MJ, et al. (1994). "Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells". J. Immunol. 151 (12): 6794–800. PMID 8258691.
Cone JC, Lu Y, Trevillyan JM, et al. (1993). "Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells". Eur. J. Immunol. 23 (10): 2488–97. doi:10.1002/eji.1830231017. PMID 8405050.
de Haas M, Koene HR, Kleijer M, et al. (1996). "A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa". J. Immunol. 156 (8): 3948–55. PMID 8609432.
Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (1997). "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene". J. Biol. Chem. 271 (48): 30755–64. doi:10.1074/jbc.271.48.30755. PMID 8940055.
Koene HR, Kleijer M, Algra J, et al. (1997). "Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype". Blood 90 (3): 1109–14. PMID 9242542.
Nourse, JP (Jan 2012). "The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms.". Blood Coagul Fibrinolysis 23 (1): 45–50. doi:10.1097/mbc.0b013e32834d7ce3. PMID 22024796.
Keane, C (Oct 2012). "Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for Diffuse Large B-cell Lymphoma.". Internal Medicine 42 (10): 1113–9. doi:10.1111/j.1445-5994.2011.02587.x. PMID 21883784.

PDB gallery

1e4j: CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN FC-GAMMA RECEPTOR III

1e4k: CRYSTAL STRUCTURE OF SOLUBLE HUMAN IGG1 FC FRAGMENT-FC-GAMMA RECEPTOR III COMPLEX

1fnl: CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII

1t83: CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (ORTHORHOMBIC)

1t89: CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (HEXAGONAL)

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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FCGR3A

References

Further reading