SEMA7A

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3NVQ​
Identifiers
Symbols	SEMA7A ; CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMAK1; SEMAL
External IDs	OMIM: 607961 MGI: 1306826 HomoloGene: 2678 GeneCards: SEMA7A Gene
Gene ontology Molecular function • integrin binding • protein binding Cellular component • plasma membrane • external side of plasma membrane • membrane • anchored component of membrane Biological process • osteoblast differentiation • inflammatory response • immune response • integrin-mediated signaling pathway • axon guidance • olfactory lobe development • positive regulation of axon extension • axon extension • regulation of inflammatory response • positive regulation of macrophage cytokine production • positive regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8482	20361
Ensembl	ENSG00000138623	ENSMUSG00000038264
UniProt	O75326	Q9QUR8
RefSeq (mRNA)	NM_001146029	NM_011352
RefSeq (protein)	NP_001139501	NP_035482
Location (UCSC)	Chr 15: 74.41 – 74.43 Mb	Chr 9: 57.94 – 57.96 Mb
PubMed search

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.^[1]

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM]^[1]

Genetics

This protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain.

Molecular biology

This protein forms dimers.

Notes

This protein acts as a receptor for the malaria parasite Plasmodium falciparum.

See also

• Cluster of differentiation

References

1. "Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)".

Further reading

• Xu X, Ng S, Wu ZL, et al. (1998). "Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins.". J. Biol. Chem. 273 (35): 22428–34. doi:10.1074/jbc.273.35.22428. PMID 9712866.
• Lange C, Liehr T, Goen M, et al. (1998). "New eukaryotic semaphorins with close homology to semaphorins of DNA viruses.". Genomics 51 (3): 340–50. doi:10.1006/geno.1998.5256. PMID 9721204.
• Yamada A, Kubo K, Takeshita T, et al. (1999). "Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108.". J. Immunol. 162 (7): 4094–100. PMID 10201933.
• Angelisová P, Drbal K, Cerný J, et al. (1999). "Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules.". Immunobiology 200 (2): 234–45. doi:10.1016/s0171-2985(99)80073-4. PMID 10416131.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
• Mine T, Harada K, Matsumoto T, et al. (2000). "CDw108 expression during T-cell development.". Tissue Antigens 55 (5): 429–36. doi:10.1034/j.1399-0039.2000.550505.x. PMID 10885563.
• Holmes S, Downs AM, Fosberry A, et al. (2002). "Sema7A is a potent monocyte stimulator.". Scand. J. Immunol. 56 (3): 270–5. doi:10.1046/j.1365-3083.2002.01129.x. PMID 12193228.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Maurin JC, Delorme G, Machuca-Gayet I, et al. (2005). "Odontoblast expression of semaphorin 7A during innervation of human dentin.". Matrix Biol. 24 (3): 232–8. doi:10.1016/j.matbio.2005.03.005. PMID 15907379.
• Hu Y, Malone JP, Fagan AM, et al. (2006). "Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid.". Mol. Cell Proteomics 4 (12): 2000–9. doi:10.1074/mcp.M500207-MCP200. PMID 16199891.
• Koh JM, Oh B, Lee JY, et al. (2006). "Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women.". J. Hum. Genet. 51 (2): 112–7. doi:10.1007/s10038-005-0331-z. PMID 16372136.

External links

• SEMA7A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• John Milton Hagen blood group system in the BGMUT blood group antigen gene mutation database

This article incorporates text from the United States National Library of Medicine, which is in the public domain.