LILRB1

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
PDB rendering based on 1g0x.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1G0X​, 1P7Q​, 1UFU​, 1UGN​, 1VDG​, 3D2U​, 4LL9​, 4NO0​
Identifiers
Symbols	LILRB1 ; CD85J; ILT-2; ILT2; LIR-1; LIR1; MIR-7; MIR7
External IDs	OMIM: 604811 HomoloGene: 88463 GeneCards: LILRB1 Gene
Gene ontology Molecular function • protein phosphatase 1 binding • HLA-A specific inhibitory MHC class I receptor activity • HLA-B specific inhibitory MHC class I receptor activity • MHC class I receptor activity • SH2 domain binding • MHC class I protein binding • protein homodimerization activity Cellular component • extracellular region • cytoplasm • plasma membrane • external side of plasma membrane • integral component of membrane Biological process • negative regulation of T cell mediated cytotoxicity • positive regulation of defense response to virus by host • adaptive immune response • T cell proliferation involved in immune response • negative regulation of cytokine secretion involved in immune response • immune response-inhibiting cell surface receptor signaling pathway • Fc receptor mediated inhibitory signaling pathway • signal transduction • response to virus • positive regulation of gene expression • negative regulation of serotonin secretion • receptor internalization • interferon-gamma production • negative regulation of interferon-gamma production • negative regulation of mononuclear cell proliferation • negative regulation of interferon-beta secretion • negative regulation of T cell proliferation • negative regulation of tumor necrosis factor biosynthetic process • positive regulation of apoptotic process • negative regulation of interferon-gamma biosynthetic process • negative regulation of cell cycle • negative regulation of endocytosis • positive regulation of cytolysis • positive regulation of transcription from RNA polymerase II promoter • negative regulation of natural killer cell mediated cytotoxicity • negative regulation of alpha-beta T cell activation • regulation of immune response • defense response to virus • negative regulation of calcium ion transport • cellular response to lipopolysaccharide • interferon-gamma secretion • dendritic cell differentiation • negative regulation of dendritic cell apoptotic process • negative regulation of interleukin-10 secretion • negative regulation of interleukin-12 secretion • negative regulation of CD8-positive, alpha-beta T cell activation • negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • positive regulation of gamma-delta T cell activation involved in immune response • negative regulation of dendritic cell differentiation • negative regulation of transforming growth factor-beta secretion • negative regulation of osteoclast development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10859	n/a
Ensembl	ENSG00000104972	n/a
UniProt	Q8NHL6	n/a
RefSeq (mRNA)	NM_001081637	n/a
RefSeq (protein)	NP_001075106	n/a
Location (UCSC)	Chr 19: 54.62 – 54.7 Mb	n/a
PubMed search		n/a

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.^[1][2]

Function

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[3]

See also

• Cluster of differentiation

References

1. Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Aug 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity 7 (2): 273–82. doi:10.1016/S1074-7613(00)80529-4. PMID 9285411.
2. Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
3. "Entrez Gene: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1".

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hirohashi N, Nakao M, Kubo K, Yamada A, Shichijo S, Hara A, Sagawa K, Itoh K (Dec 1993). "A novel antigen (H47 Ag) on human lymphocytes involved in T cell activation". Cellular Immunology 152 (2): 371–82. doi:10.1006/cimm.1993.1298. PMID 8258145.
• Samaridis J, Colonna M (Mar 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
• Wagtmann N, Rojo S, Eichler E, Mohrenweiser H, Long EO (Aug 1997). "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors". Current Biology 7 (8): 615–8. doi:10.1016/S0960-9822(06)00263-6. PMID 9259559.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
• Navarro F, Llano M, Bellón T, Colonna M, Geraghty DE, López-Botet M (Jan 1999). "The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells". European Journal of Immunology 29 (1): 277–83. doi:10.1002/(SICI)1521-4141(199901)29:01<277::AID-IMMU277>3.0.CO;2-4. PMID 9933109.
• Chapman TL, Heikeman AP, Bjorkman PJ (Nov 1999). "The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18". Immunity 11 (5): 603–13. doi:10.1016/S1074-7613(00)80135-1. PMID 10591185.
• Liu WR, Kim J, Nwankwo C, Ashworth LK, Arm JP (Jul 2000). "Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4". Immunogenetics 51 (8-9): 659–69. doi:10.1007/s002510000183. PMID 10941837.
• Chapman TL, Heikema AP, West AP, Bjorkman PJ (Nov 2000). "Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2)". Immunity 13 (5): 727–36. doi:10.1016/S1074-7613(00)00071-6. PMID 11114384.
• Lepin EJ, Bastin JM, Allan DS, Roncador G, Braud VM, Mason DY, van der Merwe PA, McMichael AJ, Bell JI, Powis SH, O'Callaghan CA (Dec 2000). "Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors". European Journal of Immunology 30 (12): 3552–61. doi:10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L. PMID 11169396.
• Young NT, Canavez F, Uhrberg M, Shum BP, Parham P (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530.
• Saverino D, Merlo A, Bruno S, Pistoia V, Grossi CE, Ciccone E (Jan 2002). "Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells". Journal of Immunology 168 (1): 207–15. doi:10.4049/jimmunol.168.1.207. PMID 11751964.
• Bellón T, Kitzig F, Sayós J, López-Botet M (Apr 2002). "Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor". Journal of Immunology 168 (7): 3351–9. doi:10.4049/jimmunol.168.7.3351. PMID 11907092.
• Nikolova M, Musette P, Bagot M, Boumsell L, Bensussan A (Aug 2002). "Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling". Blood 100 (3): 1019–25. doi:10.1182/blood-2001-12-0303. PMID 12130517.
• Willcox BE, Thomas LM, Chapman TL, Heikema AP, West AP, Bjorkman PJ (Oct 2002). "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18". BMC Structural Biology 2: 6. doi:10.1186/1472-6807-2-6. PMC 130215. PMID 12390682.
• Achdout H, Arnon TI, Markel G, Gonen-Gross T, Katz G, Lieberman N, Gazit R, Joseph A, Kedar E, Mandelboim O (Jul 2003). "Enhanced recognition of human NK receptors after influenza virus infection". Journal of Immunology 171 (2): 915–23. doi:10.4049/jimmunol.171.2.915. PMID 12847262.

External links

• LILRB1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.