Melanotransferrin

Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5

Identifiers

MFI2 ; CD228; MAP97; MTF1; MTf

External IDs

OMIM: 155750 MGI: 1353421 HomoloGene: 4335 GeneCards: MFI2 Gene

Gene ontology
Molecular function	• iron ion binding • protein binding
Cellular component	• extracellular space • integral component of plasma membrane • cell surface • anchored component of plasma membrane • extracellular exosome
Biological process	• regulation of cell growth • positive regulation of plasminogen activation • regulation of cell proliferation • iron ion homeostasis • positive regulation of extracellular matrix disassembly • iron ion import • negative regulation of substrate adhesion-dependent cell spreading
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
196.99 – 197.03 Mb

Chr 16:
31.88 – 31.9 Mb

PubMed search

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.^[1]

References

↑ "Entrez Gene: MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5".

Suryo Rahmanto Y, Dunn LL, Richardson DR (2007). "The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.". Oncogene 26 (42): 6113–24. doi:10.1038/sj.onc.1210442. PMID 17452986.
Baker EN, Baker HM, Smith CA, et al. (1992). "Human melanotransferrin (p97) has only one functional iron-binding site.". FEBS Lett. 298 (2-3): 215–8. doi:10.1016/0014-5793(92)80060-T. PMID 1544447.
Garratt RC, Jhotí H (1992). "A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function.". FEBS Lett. 305 (1): 55–61. doi:10.1016/0014-5793(92)80654-Y. PMID 1633859.
Rose TM, Plowman GD, Teplow DB, et al. (1986). "Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.". Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1261–5. doi:10.1073/pnas.83.5.1261. PMC 323055. PMID 2419904.
Furukawa KS, Furukawa K, Real FX, et al. (1989). "A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.". J. Exp. Med. 169 (2): 585–90. doi:10.1084/jem.169.2.585. PMC 2189208. PMID 2463331.
Sciot R, de Vos R, van Eyken P, et al. (1989). "In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study.". Liver 9 (2): 110–9. doi:10.1111/j.1600-0676.1989.tb00387.x. PMID 2540389.
Seligman PA, Butler CD, Massey EJ, et al. (1986). "The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor.". Am. J. Hum. Genet. 38 (4): 540–8. PMC 1684788. PMID 3010712.
Le Beau MM, Diaz MO, Plowman GD, et al. (1986). "Chromosomal sublocalization of the human p97 melanoma antigen.". Hum. Genet. 72 (4): 294–6. doi:10.1007/BF00290951. PMID 3754536.
Plowman GD, Brown JP, Enns CA, et al. (1983). "Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3.". Nature 303 (5912): 70–2. doi:10.1038/303070a0. PMID 6843660.
Kennard ML, Richardson DR, Gabathuler R, et al. (1995). "A novel iron uptake mechanism mediated by GPI-anchored human p97.". EMBO J. 14 (17): 4178–86. PMC 394500. PMID 7556058.
Food MR, Rothenberger S, Gabathuler R, et al. (1994). "Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein.". J. Biol. Chem. 269 (4): 3034–40. PMID 8300636.
Rothenberger S, Food MR, Gabathuler R, et al. (1996). "Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium.". Brain Res. 712 (1): 117–21. doi:10.1016/0006-8993(96)88505-2. PMID 8705293.
Chi DD, Merchant RE, Rand R, et al. (1997). "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.". Am. J. Pathol. 150 (6): 2143–52. PMC 1858329. PMID 9176405.
Richardson DR (2000). "The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.". Eur. J. Biochem. 267 (5): 1290–8. doi:10.1046/j.1432-1327.2000.01079.x. PMID 10691965.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.
Sekyere E, Food MR, Richardson DR (2002). "A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin?". FEBS Lett. 512 (1-3): 350–2. doi:10.1016/S0014-5793(02)02248-2. PMID 11852110.
Food MR, Sekyere EO, Richardson DR (2002). "The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein.". Eur. J. Biochem. 269 (18): 4435–45. doi:10.1046/j.1432-1033.2002.03140.x. PMID 12230555.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Guo J, Wen DR, Huang RR, et al. (2003). "Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR.". Exp. Mol. Pathol. 74 (2): 140–7. doi:10.1016/S0014-4800(03)00012-1. PMID 12710945.

External links

MFI2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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Melanotransferrin

References

Further reading

External links