KLRB1

Killer cell lectin-like receptor subfamily B, member 1

Identifiers

KLRB1 ; CD161; CLEC5B; NKR; NKR-P1; NKR-P1A; NKRP1A; hNKR-P1A

External IDs

OMIM: 602890 MGI: 107539 HomoloGene: 84369 GeneCards: KLRB1 Gene

Gene ontology
Molecular function	• transmembrane signaling receptor activity • carbohydrate binding
Cellular component	• plasma membrane • integral component of membrane
Biological process	• cell surface receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
9.59 – 9.61 Mb

Chr 6:
128.61 – 128.62 Mb

PubMed search

Killer cell lectin-like receptor subfamily B, member 1, also known as NK1.1,KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.^[1]

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus.^[1] NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.

References

1 2 "Entrez Gene: KLRB1 killer cell lectin-like receptor subfamily B, member 1".

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Lanier LL, Chang C, Phillips JH (1994). "Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.". J. Immunol. 153 (6): 2417–28. PMID 8077657.
Poggi A, Costa P, Morelli L, et al. (1996). "Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity.". Eur. J. Immunol. 26 (6): 1266–72. doi:10.1002/eji.1830260613. PMID 8647203.
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Poggi A, Costa P, Zocchi MR, Moretta L (1997). "Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration.". Eur. J. Immunol. 27 (9): 2345–50. doi:10.1002/eji.1830270932. PMID 9341779.
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Poggi A, Costa P, Tomasello E, Moretta L (1998). "IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation.". Eur. J. Immunol. 28 (5): 1611–6. doi:10.1002/(SICI)1521-4141(199805)28:05<1611::AID-IMMU1611>3.0.CO;2-6. PMID 9603467.
Carlyle JR, Martin A, Mehra A, et al. (1999). "Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function.". J. Immunol. 162 (10): 5917–23. PMID 10229828.
Ishihara S, Nieda M, Kitayama J, et al. (1999). "CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver.". Eur. J. Immunol. 29 (8): 2406–13. doi:10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F. PMID 10458753.
Iiai T, Watanabe H, Suda T, et al. (2002). "CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver.". Clin. Exp. Immunol. 129 (1): 92–8. doi:10.1046/j.1365-2249.2002.01886.x. PMC 1906419. PMID 12100027.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Iizuka K, Naidenko OV, Plougastel BF, et al. (2003). "Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors.". Nat. Immunol. 4 (8): 801–7. doi:10.1038/ni954. PMID 12858173.
Carlyle JR, Jamieson AM, Gasser S, et al. (2004). "Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3527–32. doi:10.1073/pnas.0308304101. PMC 373496. PMID 14990792.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Aldemir H, Prod'homme V, Dumaurier MJ, et al. (2006). "Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.". J. Immunol. 175 (12): 7791–5. doi:10.4049/jimmunol.175.12.7791. PMID 16339512.
Rosen DB, Bettadapura J, Alsharifi M, et al. (2006). "Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.". J. Immunol. 175 (12): 7796–9. doi:10.4049/jimmunol.175.12.7796. PMID 16339513.
Pozo D, Valés-Gómez M, Mavaddat N, et al. (2006). "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase.". J. Immunol. 176 (4): 2397–406. doi:10.4049/jimmunol.176.4.2397. PMID 16455998.
Christiansen D, Mouhtouris E, Milland J, et al. (2007). "Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161).". Xenotransplantation 13 (5): 440–6. doi:10.1111/j.1399-3089.2006.00332.x. PMID 16925668.
Rosen, DB, Cao W; et al. (2008). "Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells.". J. Immunol. 180 (10): 6508–6517. doi:10.4049/jimmunol.180.10.6508. PMC 2577150. PMID 18453569.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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KLRB1

References

Further reading