TLR 1

Toll-like receptor 1
PDB rendering based on 1fyv.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1FYV​, 2Z7X​
Identifiers
Symbols	TLR1 ; CD281; TIL; TIL. LPRS5; rsc786
External IDs	OMIM: 601194 MGI: 1341295 HomoloGene: 20694 GeneCards: TLR1 Gene
Gene ontology Molecular function • receptor activity • transmembrane signaling receptor activity • protein heterodimerization activity Cellular component • plasma membrane • integral component of plasma membrane • membrane • phagocytic vesicle membrane • Toll-like receptor 1-Toll-like receptor 2 protein complex Biological process • MyD88-dependent toll-like receptor signaling pathway • inflammatory response • immune response • signal transduction • toll-like receptor 1 signaling pathway • macrophage activation • detection of triacyl bacterial lipopeptide • positive regulation of tumor necrosis factor biosynthetic process • innate immune response • positive regulation of interleukin-6 biosynthetic process • regulation of cytokine secretion • cellular response to triacyl bacterial lipopeptide Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7096	21897
Ensembl	ENSG00000174125	ENSMUSG00000044827
UniProt	Q15399	Q9EPQ1
RefSeq (mRNA)	NM_003263	NM_001276445
RefSeq (protein)	NP_003254	NP_001263374
Location (UCSC)	Chr 4: 38.79 – 38.86 Mb	Chr 5: 64.92 – 64.93 Mb
PubMed search

TLR 1 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system.^[1][2] TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLR1 has also been designated as CD281 (cluster of differentiation 281).

TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.^[3]

TLR1 recognises peptidoglycan and (triacyl) lipoproteins in concert with TLR2 (as a heterodimer).^[4][5] Toll-like receptors, including TLR-1, found on the epithelial cell layer that lines the small and large intestine are important players the management of the gut microbiota and detection of pathogens.^[6] It is also found on the surface of macrophages and neutrophils.

Interactions

TLR 1 has been shown to interact with TLR 2.^[7]

References

1. Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF (January 1998). "A family of human receptors structurally related to Drosophila Toll". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 588–93. doi:10.1073/pnas.95.2.588. PMC 18464. PMID 9435236.
2. Lien E, Ingalls RR (January 2002). "Toll-like receptors". Crit. Care Med. 30 (1 Suppl): S1–11. doi:10.1097/00003246-200201001-00001. PMID 11782555.
3. "SRF serum response factor". Entrez Gene. National Center for Biotechnology Information, National Institutes of Health.
4. Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Röschmann K, Jung G, Wiesmüller KH, Ulmer AJ (March 2008). "Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling". J. Leukoc. Biol. 83 (3): 692–701. doi:10.1189/jlb.0807586. PMID 18056480.
5. Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO (September 2007). "Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide". Cell 130 (6): 1071–82. doi:10.1016/j.cell.2007.09.008. PMID 17889651.
6. de Kivit S, Tobin MC, Forsyth CB, Keshavarzian A, Landay AL (2014). "Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics". Frontiers in Immunology 5: 60. doi:10.3389/fimmu.2014.00060. PMC 3927311. PMID 24600450.
7. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S (Jul 2002). "Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins". J. Immunol. 169 (1): 10–4. doi:10.4049/jimmunol.169.1.10. PMID 12077222.

External links

• Toll-Like Receptor 1 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine (), which is in the public domain.