Transferrin receptor 1

Transferrin receptor
PDB rendering based on 1cx8.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1CX8​, 1DE4​, 1SUV​, 2NSU​, 3KAS​, 3S9L​, 3S9M​, 3S9N​
Identifiers
Symbols	TFRC ; CD71; T9; TFR; TFR1; TR; TRFR; p90
External IDs	OMIM: 190010 MGI: 98822 HomoloGene: 2429 GeneCards: TFRC Gene
Gene ontology Molecular function • glycoprotein binding • double-stranded RNA binding • transferrin receptor activity • protein binding • Hsp70 protein binding • transferrin transmembrane transporter activity • identical protein binding • protein homodimerization activity • poly(A) RNA binding • chaperone binding Cellular component • extracellular region • extracellular space • mitochondrion • endosome • plasma membrane • integral component of plasma membrane • coated pit • external side of plasma membrane • cell surface • membrane • cytoplasmic membrane-bounded vesicle • basolateral plasma membrane • melanosome • intracellular membrane-bounded organelle • perinuclear region of cytoplasm • recycling endosome • recycling endosome membrane • extracellular exosome • blood microparticle • extracellular vesicle • HFE-transferrin receptor complex Biological process • regulation of cell growth • response to hypoxia • cellular iron ion homeostasis • receptor-mediated endocytosis • acute-phase response • aging • response to nutrient • response to iron ion • response to manganese ion • viral process • osteoclast differentiation • response to retinoic acid • transferrin transport • cellular response to drug • regulation of cell proliferation • positive regulation of bone resorption • response to copper ion • transmembrane transport • iron ion import Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7037	22042
Ensembl	ENSG00000072274	ENSMUSG00000022797
UniProt	P02786	Q62351
RefSeq (mRNA)	NM_001128148	NM_011638
RefSeq (protein)	NP_001121620	NP_035768
Location (UCSC)	Chr 3: 196.03 – 196.08 Mb	Chr 16: 32.61 – 32.63 Mb
PubMed search

Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene.^[1][2] TfR1 is required for iron import from transferrin into cells by endocytosis.^[3][4]

Structure and function

TfR1 = transferrin receptor 1 in Human iron metabolism.

TfR1 is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis.^[5]

Clinical significance

TfR1 as a potential new target in cases of human leukemia & lymphoma. InatherYs, in Évry, France, developed a candidate drug, INA01 antibody (anti-CD71) that showed efficacy in pre-clinical studies in the therapy of two incurable orphan oncohematological diseases: the adult T cell leukemia (ATLL) caused by HTLV-1 and the Mantle cell lymphoma (MCL).

Interactions

TfR1 has been shown to interact with GABARAP^[6] and HFE.^[7][8]

See also

• Transferrin receptor 2
• Cluster of differentiation

References

1. Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (July 1981). "Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515–9. doi:10.1073/pnas.78.7.4515. PMC: 319822. PMID 6270680.
2. Rabin M, McClelland A, Kühn L, Ruddle FH (November 1985). "Regional localization of the human transferrin receptor gene to 3q26.2----qter". Am. J. Hum. Genet. 37 (6): 1112–6. PMC: 1684729. PMID 3002171.
3. Aisen P (November 2004). "Transferrin receptor 1". Int. J. Biochem. Cell Biol. 36 (11): 2137–43. doi:10.1016/j.biocel.2004.02.007. PMID 15313461.
4. Moos T (November 2002). "Brain iron homeostasis". Danish Medical Bulletin 49 (4): 279–301. PMID 12553165.
5. Speeckaert MM, Speeckaert R, Delanghe JR (December 2010). "Biological and clinical aspects of soluble transferrin receptor". Critical Reviews in Clinical Laboratory Sciences 47 (5-6): 213–228. doi:10.3109/10408363.2010.550461. PMID 21391831.
6. Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP". FEBS Lett. 518 (1–3): 101–6. doi:10.1016/S0014-5793(02)02655-8. PMID 11997026.
7. Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (February 1998). "The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472–7. doi:10.1073/pnas.95.4.1472. PMC: 19050. PMID 9465039.
8. West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (December 2000). "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE". J. Biol. Chem. 275 (49): 38135–8. doi:10.1074/jbc.C000664200. PMID 11027676.