CD79
CD79 (Cluster of Differentiation 79) is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following recognition of antigen by the BCR. CD79 is composed of two distinct chains called CD79A and CD79B (formerly known as Ig-alpha and Ig-beta); these form a heterodimer on the surface of a B cell stabilized by disulfide bonding.[1] CD79a and CD79b are both members of the immunoglobulin superfamily. Human CD79a is encoded by the mb-1 gene that is located on chromosome 19, and CD79b is encoded by the B29 gene that located on chromosome 17.[1][2] Both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to propagate a signal in a B cell, in a similar manner to CD3-generated signal tranduction observed during T cell receptor activation on T cells.[3]
References
- 1 2 Chu P, Arber D (2001). "CD79: a review". Appl Immunohistochem Mol Morphol 9 (2): 97–106. doi:10.1097/00022744-200106000-00001. PMID 11396639.
- ↑ Van Noesel C, Brouns G, van Schijndel G, Bende R, Mason D, Borst J, van Lier R (1992). "Comparison of human B cell antigen receptor complexes: membrane- expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers". J Exp Med 175 (6): 1511–9. doi:10.1084/jem.175.6.1511. PMC 2119249. PMID 1375264.
- ↑ Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol Lett 44 (2–3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.
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