CD16

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Identifiers
Symbol	FCGR3A
Alt. symbols	FCGR3, FCG3
Entrez	2214
HUGO	3619
OMIM	146740
RefSeq	NM_000569
UniProt	P08637
Other data
Locus	Chr. 1 q23

Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Identifiers
Symbol	FCGR3B
Alt. symbols	FCGR3, FCG3
Entrez	2215
HUGO	3620
OMIM	610665
RefSeq	NM_000570
UniProt	O75015
Other data
Locus	Chr. 1 q23

CD16 is a low affinity Fc receptor.

It is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.^[1] It can be used to isolate populations of these cells by antibodies directed towards CD16, using fluorescent-activated cell sorting or magnetic-activated cell sorting.

Function

CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies which then activates the NK cell for antibody-dependent cell-mediated cytotoxicity. A lack of CD16 in a given population of neutrophils may indicate prematurity, as could be caused by a left shift due to neutrophilic leukocytosis induced by tissue necrosis or bacterial infection.^[2]

References

↑ Janeway, Charles (2001). "Appendix II. CD antigens". Immunobiology (5 ed.). New York: Garland. ISBN 0-8153-3642-X.
↑ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470096/

External links

CD16 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Cluster of differentiation by lineage

Lymphoid

B cell

plasma cell: CD38
CD138

T/NK

T cell	Pan-T antigens: CD3 CD7 CD1 CD4 CD8 CD13 CD18 CD26 CD27 CD28

NK cell	CD16 CD56/NCAM CD57

All	CD2

All

Myeloid

CFU-GM/
Myelomonocyte

MEP

CFU-Meg	CD34/CD36 CD42 CD41/CD61

CFU-E	CD36 CD71

All (pan-myeloid)

CD13
CD33

Stem cell

CD34

Transmembrane receptors: immunoglobulin superfamily immune receptors

Antibody receptor:
Fc receptor

Epsilon (ε)	FcεRI (FcεRII is C-type lectin)

Gamma (γ)	FcγRI FcγRII FcγRIII Neonatal

Alpha (α)/mu (μ)	FcαRI Fcα/μR

Secretory	Polymeric immunoglobulin receptor

Antigen receptor

B cells

Antigen receptor

Co-receptor

stimulate:	CD21/CD19/CD81

inhibit:	CD22

Accessory molecules

Ig-α/Ig-β (CD79)

T cells

Ligands	MHC MHC class I MHC class II

Antigen receptor	TCR: TRA@ TRB@ TRD@ TRG@

Co-receptors	CD8 (with two glycoprotein chains CD8α and CD8β) CD4

Accessory molecules	CD3 CD3γ CD3δ CD3ε ζ-chain (also called CD3ζ and TCRζ)

Cytokine receptor

see cytokine receptors

Killer-cell IG-like receptors

KIR2DL1
KIR2DL2
KIR2DL3
KIR2DL4
KIR2DL5A
KIR2DL5B
KIR2DS1
KIR2DS2
KIR2DS3
KIR2DS4
KIR2DS5
KIR3DL1
KIR3DL2
KIR3DL3
KIR3DS1

Leukocyte IG-like receptors

LILRA1
LILRA2
LILRA3
LILRA4
LILRA5
LILRA6
LILRB1
LILRB2
LILRB3
LILRB4
LILRB5
LILRA6
LILRA5

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