Granulocyte macrophage colony-stimulating factor receptor

Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3CXE​
Identifiers
Symbols	CSF2RA ; CD116; CDw116; CSF2R; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR; GMR; SMDP4
External IDs	OMIM: 425000 MGI: 1339754 HomoloGene: 48406 ChEMBL: 2020 GeneCards: CSF2RA Gene
Gene ontology Molecular function • receptor activity • granulocyte colony-stimulating factor receptor activity • protein binding • granulocyte colony-stimulating factor binding Cellular component • extracellular region • plasma membrane • integral component of plasma membrane Biological process • granulocyte colony-stimulating factor signaling pathway • cellular response to granulocyte macrophage colony-stimulating factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1438	12982
Ensembl	ENSG00000198223	ENSMUSG00000059326
UniProt	P15509	Q00941
RefSeq (mRNA)	NM_001161529	NM_009970
RefSeq (protein)	NP_001155001	NP_034100
Location (UCSC)	Chr X: 1.27 – 1.31 Mb	Chr 19: 61.22 – 61.23 Mb
PubMed search

The granulocyte macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.^[1]

It is associated with Surfactant metabolism dysfunction type 4.

Structure

The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.^[2] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.^[3]

Signal transduction

Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family.^[3] This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.^[4]

References

1. Nicola NA, Metcalf D (Aug 1985). "Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells". Journal of Cellular Physiology 124 (2): 313–21. doi:10.1002/jcp.1041240222. PMID 3876343.
2. McClure BJ, Hercus TR, Cambareri BA, Woodcock JM, Bagley CJ, Howlett GJ, Lopez AF (Feb 2003). "Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex". Blood 101 (4): 1308–15. doi:10.1182/blood-2002-06-1903. PMID 12393492.
3. Geijsen N, Koenderman L, Coffer PJ (Mar 2001). "Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family". Cytokine & Growth Factor Reviews 12 (1): 19–25. doi:10.1016/S1359-6101(00)00019-8. PMID 11312115.
4. Doyle SE, Gasson JC (Aug 1998). "Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5" (– ^{Scholar search}). Blood 92 (3): 867–76. PMID 9680354.

Further reading

• Rappold G, Willson TA, Henke A, Gough NM (Oct 1992). "Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region". Genomics 14 (2): 455–61. doi:10.1016/S0888-7543(05)80241-1. PMID 1358805.
• Hayashida K, Kitamura T, Gorman DM, Arai K, Yokota T, Miyajima A (Dec 1990). "Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor". Proceedings of the National Academy of Sciences of the United States of America 87 (24): 9655–9. doi:10.1073/pnas.87.24.9655. PMC 55231. PMID 1702217.
• Crosier KE, Wong GG, Mathey-Prevot B, Nathan DG, Sieff CA (Sep 1991). "A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain". Proceedings of the National Academy of Sciences of the United States of America 88 (17): 7744–8. doi:10.1073/pnas.88.17.7744. PMC 52379. PMID 1715577.
• Raines MA, Liu L, Quan SG, Joe V, DiPersio JF, Golde DW (Sep 1991). "Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor". Proceedings of the National Academy of Sciences of the United States of America 88 (18): 8203–7. doi:10.1073/pnas.88.18.8203. PMC 52475. PMID 1832774.
• Gough NM, Gearing DP, Nicola NA, Baker E, Pritchard M, Callen DF, Sutherland GR (Jun 1990). "Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region". Nature 345 (6277): 734–6. doi:10.1038/345734a0. PMID 1972780.
• Ashworth A, Kraft A (Dec 1990). "Cloning of a potentially soluble receptor for human GM-CSF". Nucleic Acids Research 18 (23): 7178. doi:10.1093/nar/18.23.7178. PMC 332824. PMID 2148207.
• Gearing DP, King JA, Gough NM, Nicola NA (Dec 1989). "Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor". The EMBO Journal 8 (12): 3667–76. PMC 402049. PMID 2555171.
• DiPersio J, Billing P, Kaufman S, Eghtesady P, Williams RE, Gasson JC (Feb 1988). "Characterization of the human granulocyte-macrophage colony-stimulating factor receptor". The Journal of Biological Chemistry 263 (4): 1834–41. PMID 2828352.
• Williams WV, VonFeldt JM, Rosenbaum H, Ugen KE, Weiner DB (Oct 1994). "Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution". Arthritis and Rheumatism 37 (10): 1468–78. doi:10.1002/art.1780371010. PMID 7945472.
• Jubinsky PT, Laurie AS, Nathan DG, Yetz-Aldepe J, Sieff CA (Dec 1994). "Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit". Blood 84 (12): 4174–85. PMID 7994031.
• Hu X, Emanuel PD, Zuckerman KS (Sep 1994). "Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor". Biochimica Et Biophysica Acta 1223 (2): 306–8. doi:10.1016/0167-4889(94)90241-0. PMID 8086503.
• Nakagawa Y, Kosugi H, Miyajima A, Arai K, Yokota T (Apr 1994). "Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily". The Journal of Biological Chemistry 269 (14): 10905–12. PMID 8144676.
• Zhao Y, Rong H, Chegini N (Oct 1995). "Expression and selective cellular localization of granulocyte-macrophage colony-stimulating factor (GM-CSF) and GM-CSF alpha and beta receptor messenger ribonucleic acid and protein in human ovarian tissue". Biology of Reproduction 53 (4): 923–30. doi:10.1095/biolreprod53.4.923. PMID 8547489.
• Lia F, Rajotte D, Clark SC, Hoang T (Nov 1996). "A dominant negative granulocyte-macrophage colony-stimulating factor receptor alpha chain reveals the multimeric structure of the receptor complex". The Journal of Biological Chemistry 271 (45): 28287–93. doi:10.1074/jbc.271.45.28287. PMID 8910448.
• Wei S, Liu JH, Epling-Burnette PK, Gamero AM, Ussery D, Pearson EW, Elkabani ME, Diaz JI, Djeu JY (Dec 1996). "Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor". Journal of Immunology 157 (11): 5155–62. PMID 8943427.
• Soldi R, Primo L, Brizzi MF, Sanavio F, Aglietta M, Polentarutti N, Pegoraro L, Mantovani A, Bussolino F (Feb 1997). "Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage colony-stimulating factor". Blood 89 (3): 863–72. PMID 9028317.
• Matsuguchi T, Zhao Y, Lilly MB, Kraft AS (Jul 1997). "The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation". The Journal of Biological Chemistry 272 (28): 17450–9. doi:10.1074/jbc.272.28.17450. PMID 9211889.
• Rivas CI, Vera JC, Delgado-López F, Heaney ML, Guaiquil VH, Zhang RH, Scher HI, Concha II, Nualart F, Cordon-Cardo C, Golde DW (Feb 1998). "Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer". Blood 91 (3): 1037–43. PMID 9446667.
• Hu X, Zuckerman KS (Jun 1998). "Cloning and sequencing of an alternative splicing-derived cDNA variant of the GM-CSF receptor alpha subunit, which encodes a truncated protein". American Journal of Hematology 58 (2): 145–7. doi:10.1002/(SICI)1096-8652(199806)58:2<145::AID-AJH11>3.0.CO;2-A. PMID 9625584.
• Taha RA, Leung DY, Ghaffar O, Boguniewicz M, Hamid Q (Aug 1998). "In vivo expression of cytokine receptor mRNA in atopic dermatitis". The Journal of Allergy and Clinical Immunology 102 (2): 245–50. doi:10.1016/S0091-6749(98)70093-4. PMID 9723668.

External links

• GM-CSF Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)