CD24

CD24 molecule
Identifiers
Symbols	CD24 ; CD24A
External IDs	OMIM: 600074 HomoloGene: 122183 GeneCards: CD24 Gene
Gene ontology Molecular function • signal transducer activity • protein binding • protein kinase binding • protein tyrosine kinase activator activity Cellular component • intracellular • cytosol • plasma membrane • cell surface • membrane • anchored component of membrane • membrane raft Biological process • response to hypoxia • cell activation • regulation of cytokine-mediated signaling pathway • response to molecule of bacterial origin • immune response-regulating cell surface receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • axon guidance • Wnt signaling pathway • single organismal cell-cell adhesion • cell migration • regulation of epithelial cell differentiation • T cell costimulation • B cell receptor transport into membrane raft • chemokine receptor transport out of membrane raft • negative regulation of transforming growth factor beta3 production • positive regulation of activated T cell proliferation • regulation of phosphorylation • cholesterol homeostasis • positive regulation of MAP kinase activity • regulation of MAPK cascade • response to estrogen • respiratory burst • positive regulation of protein tyrosine kinase activity • glomerular visceral epithelial cell differentiation • glomerular parietal epithelial cell differentiation • intrinsic apoptotic signaling pathway • positive regulation of nephron tubule epithelial cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	100133941	n/a
Ensembl	ENSG00000272398	n/a
UniProt	P25063	n/a
RefSeq (mRNA)	NM_001291737	n/a
RefSeq (protein)	NP_001278666	n/a
Location (UCSC)	Chr 6: 106.97 – 106.98 Mb	n/a
PubMed search		n/a

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene.^[1] CD24 is a cell adhesion molecule.

Function

CD24 is a glycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined (source: NCBI).

References

1. Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (July 1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics 22 (1): 154–61. doi:10.1006/geno.1994.1356. PMID 7959762.

Further reading

• Li D, Zheng L, Jin L; et al. (2009). "CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection.". Hepatology 50 (3): 735–42. doi:10.1002/hep.23047. PMID 19610054.
• Piotrowski P, Lianeri M, Wudarski M; et al. (2010). "CD24 Ala57Val gene polymorphism and the risk of systemic lupus erythematosus.". Tissue Antigens 75 (6): HASH(0x2aadb3dd8b00). doi:10.1111/j.1399-0039.2010.01447.x. PMID 20230526.
• Honeth G, Bendahl PO, Ringnér M; et al. (2008). "The CD44+/CD24- phenotype is enriched in basal-like breast tumors". Breast Cancer Res. 10 (3): R53. doi:10.1186/bcr2108. PMC 2481503. PMID 18559090.
• Nagy B, Szendroi A, Romics I (2009). "Overexpression of CD24, c-myc and phospholipase 2A in prostate cancer tissue samples obtained by needle biopsy". Pathol. Oncol. Res. 15 (2): 279–83. doi:10.1007/s12253-008-9077-1. PMID 18752058.
• Kim KH, Choi JS, Kim JM; et al. (2009). "Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium". Histol. Histopathol. 24 (3): 309–16. PMID 19130400.
• Buess M, Rajski M, Vogel-Durrer BM; et al. (2009). "Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer". Neoplasia 11 (10): 987–1002. PMC 2745665. PMID 19794958.
• Pruszak J, Ludwig W, Blak A; et al. (2009). "CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells". Stem Cells 27 (12): 2928–40. doi:10.1002/stem.211. PMC 3322476. PMID 19725119.
• Liu Y, Chen GY, Zheng P (2009). "CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns". Trends Immunol. 30 (12): 557–61. doi:10.1016/j.it.2009.09.006. PMC 2788100. PMID 19786366.
• Vesuna F, Lisok A, Kimble B, Raman V (2009). "Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression". Neoplasia 11 (12): 1318–28. PMC 2794513. PMID 20019840.
• Sagiv E, Arber N (2008). "The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy". Expert review of gastroenterology & hepatology 2 (1): 125–33. doi:10.1586/17474124.2.1.125. PMID 19072375.
• Bauerschmitz GJ, Ranki T, Kangasniemi L; et al. (2008). "Tissue-specific promoters active in CD44+CD24-/low breast cancer cells". Cancer Res. 68 (14): 5533–9. doi:10.1158/0008-5472.CAN-07-5288. PMID 18632604.
• Carl JW, Liu JQ, Joshi PS; et al. (2008). "Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway". J. Immunol. 181 (1): 320–8. doi:10.4049/jimmunol.181.1.320. PMID 18566397.
• Baumhoer D, Riener MO, Zlobec I; et al. (2009). "Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater". Mod. Pathol. 22 (2): 306–13. doi:10.1038/modpathol.2008.192. PMID 19043399.
• Wang W, Wang X, Peng L; et al. (2010). "CD24-dependent MAPK pathway activation is required for colorectal cancer cell proliferation". Cancer Sci. 101 (1): 112–9. doi:10.1111/j.1349-7006.2009.01370.x. PMID 19860845.
• Sano A, Kato H, Sakurai S; et al. (2009). "CD24 expression is a novel prognostic factor in esophageal squamous cell carcinoma". Ann. Surg. Oncol. 16 (2): 506–14. doi:10.1245/s10434-008-0252-0. PMID 19050962.
• Yang XR, Xu Y, Yu B; et al. (2009). "CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery". Clin. Cancer Res. 15 (17): 5518–27. doi:10.1158/1078-0432.CCR-09-0151. PMID 19706825.
• Lee JH, Kim SH, Lee ES, Kim YS (2009). "CD24 overexpression in cancer development and progression: a meta-analysis". Oncol. Rep. 22 (5): 1149–56. doi:10.3892/or_00000548. PMID 19787233.
• Gekara NO, Weiss S (2004). "Lipid rafts clustering and signalling by listeriolysin O". Biochem. Soc. Trans. 32 (Pt 5): 712–4. doi:10.1042/BST0320712. PMID 15493995.
• Athanassiadou P, Grapsa D, Gonidi M; et al. (2009). "CD24 expression has a prognostic impact in breast carcinoma". Pathol. Res. Pract. 205 (8): 524–33. doi:10.1016/j.prp.2009.01.008. PMID 19243896.
• Ronaghi M, Vallian S, Etemadifar M (2009). "CD24 gene polymorphism is associated with the disease progression and susceptibility to multiple sclerosis in the Iranian population". Psychiatry Res 170 (2–3): 271–2. doi:10.1016/j.psychres.2009.01.002. PMID 19896210.

External links

• CD24 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
• Mouse CD Antigen Chart
• Human CD Antigen Chart
• www.copewithcytokines.de: description of CD24 expression
• CD24 human gene location in the UCSC Genome Browser.
• CD24 human gene details in the UCSC Genome Browser.