Interleukin-7 receptor-α

Interleukin 7 receptor
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3DI2​, 3DI3​, 3UP1​
Identifiers
Symbols	IL7R ; CD127; CDW127; IL-7R-alpha; IL7RA; ILRA
External IDs	OMIM: 146661 MGI: 96562 HomoloGene: 1646 GeneCards: IL7R Gene
Gene ontology Molecular function • antigen binding • interleukin-7 receptor activity • protein binding Cellular component • extracellular region • plasma membrane • external side of plasma membrane • integral component of membrane Biological process • regulation of DNA recombination • cell morphogenesis • negative regulation of T cell mediated cytotoxicity • immunoglobulin production • immune response • signal transduction • cell surface receptor signaling pathway • regulation of cell size • positive regulation of gene expression • cell growth • T cell differentiation • positive regulation of T cell differentiation in thymus • interleukin-7-mediated signaling pathway • B cell proliferation • lymph node development • homeostasis of number of cells Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3575	16197
Ensembl	ENSG00000168685	ENSMUSG00000003882
UniProt	P16871	P16872
RefSeq (mRNA)	NM_002185	NM_008372
RefSeq (protein)	NP_002176	NP_032398
Location (UCSC)	Chr 5: 35.85 – 35.88 Mb	Chr 15: 9.51 – 9.53 Mb
PubMed search

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.^[1][2]

IL7R-α is a type I cytokine receptor and is a subunit of the functional Interleukin-7 receptor and Thymic Stromal Lymphopoietin (TSLP) receptors.

References

1. "Entrez Gene: IL7R interleukin 7 receptor".
2. Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE (March 1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily". Cell 60 (6): 941–51. doi:10.1016/0092-8674(90)90342-C. PMID 2317865.

Further reading

• Akashi K, Kondo M, Weissman IL (1999). "Role of interleukin-7 in T-cell development from hematopoietic stem cells.". Immunol. Rev. 165: 13–28. doi:10.1111/j.1600-065X.1998.tb01226.x. PMID 9850848.
• Appasamy PM (1999). "Biological and clinical implications of interleukin-7 and lymphopoiesis.". Cytokines Cell. Mol. Ther. 5 (1): 25–39. PMID 10390077.
• Al-Rawi MA, Mansel RE, Jiang WG (2004). "Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.". Histol. Histopathol. 18 (3): 911–23. PMID 12792903.
• Banham AH (2007). "Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells.". Trends Immunol. 27 (12): 541–4. doi:10.1016/j.it.2006.10.002. PMID 17045841.
• Nishii K, Kita K, Miwa H, et al. (1992). "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13.". Leukemia 6 (7): 662–8. PMID 1378163.
• Lynch M, Baker E, Park LS, et al. (1992). "The interleukin-7 receptor gene is at 5p13.". Hum. Genet. 89 (5): 566–8. doi:10.1007/BF00219186. PMID 1634235.
• Pleiman CM, Gimpel SD, Park LS, et al. (1991). "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter.". Mol. Cell. Biol. 11 (6): 3052–9. PMC 360143. PMID 2038316.
• Seckinger P, Fougereau M (1994). "Activation of src family kinases in human pre-B cells by IL-7.". J. Immunol. 153 (1): 97–109. PMID 7515933.
• van der Plas DC, Smiers F, Pouwels K, et al. (1996). "Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.". Leukemia 10 (8): 1317–25. PMID 8709637.
• Maraskovsky E, O'Reilly LA, Teepe M, et al. (1997). "Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice.". Cell 89 (7): 1011–9. doi:10.1016/S0092-8674(00)80289-5. PMID 9215624.
• Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR (1998). "Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor.". Nature 391 (6670): 904–7. doi:10.1038/36122. PMID 9495344.
• Puel A, Ziegler SF, Buckley RH, Leonard WJ (1998). "Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.". Nat. Genet. 20 (4): 394–7. doi:10.1038/3877. PMID 9843216.
• Ye SK, Maki K, Kitamura T, et al. (1999). "Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor.". Immunity 11 (2): 213–23. doi:10.1016/S1074-7613(00)80096-5. PMID 10485656.
• Benbernou N, Muegge K, Durum SK (2000). "Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha.". J. Biol. Chem. 275 (10): 7060–5. doi:10.1074/jbc.275.10.7060. PMID 10702271.
• Roifman CM, Zhang J, Chitayat D, Sharfe N (2000). "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency.". Blood 96 (8): 2803–7. PMID 11023514.
• Reche PA, Soumelis V, Gorman DM, et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.". J. Immunol. 167 (1): 336–43. doi:10.4049/jimmunol.167.1.336. PMID 11418668.

External links

• IL7R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.