Leukemia inhibitory factor receptor

Leukemia inhibitory factor receptor alpha
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3E0G​
Identifiers
Symbols	LIFR ; CD118; LIF-R; SJS2; STWS; SWS
External IDs	OMIM: 151443 MGI: 96788 HomoloGene: 1735 GeneCards: LIFR Gene
Gene ontology Molecular function • ciliary neurotrophic factor receptor activity • leukemia inhibitory factor receptor activity • oncostatin-M receptor activity • ciliary neurotrophic factor receptor binding • growth factor binding • cytokine binding • protein heterodimerization activity Cellular component • integral component of plasma membrane • receptor complex • extracellular exosome Biological process • cell surface receptor signaling pathway • positive regulation of cell proliferation • negative regulation of muscle cell apoptotic process • response to organic cyclic compound • cytokine-mediated signaling pathway • organ regeneration • response to cytokine • oncostatin-M-mediated signaling pathway • neuron projection morphogenesis • leukemia inhibitory factor signaling pathway • ciliary neurotrophic factor-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3977	16880
Ensembl	ENSG00000113594	ENSMUSG00000054263
UniProt	P42702	P42703
RefSeq (mRNA)	NM_001127671	NM_001113386
RefSeq (protein)	NP_001121143	NP_001106857
Location (UCSC)	Chr 5: 38.47 – 38.61 Mb	Chr 15: 7.13 – 7.2 Mb
PubMed search

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.^[1]

Interactions

Leukemia inhibitory factor receptor has been shown to interact with Glycoprotein 130.^[2][3]

LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.

See also

• Cluster of differentiation

References

1. "Entrez Gene: LIFR leukemia inhibitory factor receptor alpha".
2. Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G (Jun 2002). "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor". Eur. J. Biochem. (Germany) 269 (11): 2716–26. doi:10.1046/j.1432-1033.2002.02941.x. ISSN 0014-2956. PMID 12047380.
3. Mosley, B; De Imus C; Friend D; Boiani N; Thoma B; Park L S; Cosman D (Dec 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. (UNITED STATES) 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. ISSN 0021-9258. PMID 8999038.

Further reading

• Tomida M (2003). "Structural and functional studies on the leukemia inhibitory factor receptor (LIF-R): gene and soluble form of LIF-R, and cytoplasmic domain of LIF-R required for differentiation and growth arrest of myeloid leukemic cells.". Leuk. Lymphoma 37 (5–6): 517–25. doi:10.3109/10428190009058503. PMID 11042511.
• Lass A, Weiser W, Munafo A, Loumaye E (2002). "Leukemia inhibitory factor in human reproduction". Fertil. Steril. 76 (6): 1091–6. doi:10.1016/S0015-0282(01)02878-3. PMID 11730732.
• Gearing DP, Bruce AG (1992). "Oncostatin M binds the high-affinity leukemia inhibitory factor receptor". New Biol. 4 (1): 61–5. PMID 1536831.
• Gearing DP, Comeau MR, Friend DJ, et al. (1992). "The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor". Science 255 (5050): 1434–7. doi:10.1126/science.1542794. PMID 1542794.
• Gearing DP, Thut CJ, VandeBos T, et al. (1991). "Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130". EMBO J. 10 (10): 2839–48. PMC 452994. PMID 1915266.
• Boulton TG, Stahl N, Yancopoulos GD (1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors". J. Biol. Chem. 269 (15): 11648–55. PMID 7512571.
• Schiemann WP, Graves LM, Baumann H, et al. (1995). "Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5361–5. doi:10.1073/pnas.92.12.5361. PMC 41694. PMID 7777512.
• Gearing DP, Druck T, Huebner K, et al. (1994). "The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13". Genomics 18 (1): 148–50. doi:10.1006/geno.1993.1441. PMID 8276403.
• Sharkey AM, Dellow K, Blayney M, et al. (1996). "Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos". Biol. Reprod. 53 (4): 974–81. doi:10.1095/biolreprod53.4.974. PMID 8547494.
• Kojima K, Kanzaki H, Iwai M, et al. (1996). "Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts". Hum. Reprod. 10 (7): 1907–11. PMID 8583009.
• Tomida M, Gotoh O (1997). "Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor". J. Biochem. 120 (1): 201–5. doi:10.1093/oxfordjournals.jbchem.a021386. PMID 8864865.
• Wang Z, Melmed S (1997). "Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage". J. Biol. Chem. 272 (44): 27957–65. doi:10.1074/jbc.272.44.27957. PMID 9346946.
• Tanaka M, Hara T, Copeland NG, et al. (1999). "Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit". Blood 93 (3): 804–15. PMID 9920829.
• Knight DA, Lydell CP, Zhou D, et al. (1999). "Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release". Am. J. Respir. Cell Mol. Biol. 20 (4): 834–41. doi:10.1165/ajrcmb.20.4.3429. PMID 10101017.
• Kakizawa T, Miyamoto T, Ichikawa K, et al. (1999). "Functional interaction between Oct-1 and retinoid X receptor". J. Biol. Chem. 274 (27): 19103–8. doi:10.1074/jbc.274.27.19103. PMID 10383413.
• Bartoe JL, Nathanson NM (2000). "Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways". J. Neurochem. 74 (5): 2021–32. doi:10.1046/j.1471-4159.2000.0742021.x. PMID 10800945.
• Bamberger AM, Schulte HM, Wullbrand A, et al. (2000). "Expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF-R) in the human adrenal cortex: implications for steroidogenesis". Mol. Cell. Endocrinol. 162 (1–2): 145–9. doi:10.1016/S0303-7207(00)00200-8. PMID 10854707.
• Blanchard F, Duplomb L, Wang Y, et al. (2000). "Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase". J. Biol. Chem. 275 (37): 28793–801. doi:10.1074/jbc.M003986200. PMID 10858440.
• Plun-Favreau H, Elson G, Chabbert M, et al. (2001). "The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine". EMBO J. 20 (7): 1692–703. doi:10.1093/emboj/20.7.1692. PMC 145510. PMID 11285233.

External links

• LIF Receptor alpha Subunit at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.