CCR1

Chemokine (C-C motif) receptor 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Y5D​
Identifiers
Symbols	CCR1 ; CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR; SCYAR1
External IDs	OMIM: 601159 MGI: 104618 HomoloGene: 20344 IUPHAR: 58 ChEMBL: 2413 GeneCards: CCR1 Gene
Gene ontology Molecular function • phosphatidylinositol phospholipase C activity • chemokine receptor activity • protein binding • C-C chemokine receptor activity • C-C chemokine binding • chemokine (C-C motif) ligand 7 binding • chemokine (C-C motif) ligand 5 binding Cellular component • cytosol • plasma membrane • integral component of plasma membrane • external side of plasma membrane Biological process • dendritic cell chemotaxis • calcium ion transport • cellular calcium ion homeostasis • exocytosis • chemotaxis • inflammatory response • immune response • cell adhesion • cell surface receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • positive regulation of cytosolic calcium ion concentration • cell-cell signaling • response to wounding • negative regulation of gene expression • cytokine-mediated signaling pathway • positive regulation of cell migration • negative regulation of bone mineralization • positive regulation of osteoclast differentiation • positive regulation of calcium ion transport • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • positive regulation of monocyte chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1230	12768
Ensembl	ENSG00000163823	ENSMUSG00000025804
UniProt	P32246	P51675
RefSeq (mRNA)	NM_001295	NM_009912
RefSeq (protein)	NP_001286	NP_034042
Location (UCSC)	Chr 3: 46.2 – 46.21 Mb	Chr 9: 123.96 – 123.97 Mb
PubMed search

C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.^[1]

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.^[2]

Interactions

CCR1 has been shown to interact with CCL5.^[3][4]

References

1. Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (Mar 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell 72 (3): 415–25. doi:10.1016/0092-8674(93)90118-A. PMID 7679328.
2. "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1".
3. Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (Jul 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. (Germany) 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. ISSN 0014-2980. PMID 11449371.
4. Proudfoot, A E; Fritchley S; Borlat F; Shaw J P; Vilbois F; Zwahlen C; Trkola A; Marchant D; Clapham P R; Wells T N (Apr 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". J. Biol. Chem. (United States) 276 (14): 10620–6. doi:10.1074/jbc.M010867200. ISSN 0021-9258. PMID 11116158.

Further reading

• Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor.". Annu. Rev. Immunol. 12 (1): 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
• Ruibal-Ares BH, Belmonte L, Baré PC; et al. (2004). "HIV-1 infection and chemokine receptor modulation.". Curr. HIV Res. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339.
• Nomura H, Nielsen BW, Matsushima K (1994). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.". Int. Immunol. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609.
• Ben-Baruch A, Xu L, Young PR; et al. (1995). "Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3.". J. Biol. Chem. 270 (38): 22123–8. doi:10.1074/jbc.270.38.22123. PMID 7545673.
• Post TW, Bozic CR, Rothenberg ME; et al. (1995). "Molecular characterization of two murine eosinophil beta chemokine receptors.". J. Immunol. 155 (11): 5299–305. PMID 7594543.
• Gao JL, Kuhns DB, Tiffany HL; et al. (1993). "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.". J. Exp. Med. 177 (5): 1421–7. doi:10.1084/jem.177.5.1421. PMC 2191019. PMID 7683036.
• Combadiere C, Ahuja SK, Van Damme J; et al. (1996). "Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B.". J. Biol. Chem. 270 (50): 29671–5. doi:10.1074/jbc.270.50.29671. PMID 8530354.
• Kuang Y, Wu Y, Jiang H, Wu D (1996). "Selective G protein coupling by C-C chemokine receptors.". J. Biol. Chem. 271 (8): 3975–8. doi:10.1074/jbc.271.8.3975. PMID 8626727.
• Boring L, Gosling J, Monteclaro FS; et al. (1996). "Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9.". J. Biol. Chem. 271 (13): 7551–8. doi:10.1074/jbc.271.13.7551. PMID 8631787.
• Gong X, Gong W, Kuhns DB; et al. (1997). "Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors.". J. Biol. Chem. 272 (18): 11682–5. doi:10.1074/jbc.272.18.11682. PMID 9115216.
• Daugherty BL, Springer MS (1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21.". Genomics 41 (2): 294–5. doi:10.1006/geno.1997.4626. PMID 9143512.
• Pakianathan DR, Kuta EG, Artis DR; et al. (1997). "Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5.". Biochemistry 36 (32): 9642–8. doi:10.1021/bi970593z. PMID 9289016.
• Coulin F, Power CA, Alouani S; et al. (1997). "Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines.". Eur. J. Biochem. 248 (2): 507–15. doi:10.1111/j.1432-1033.1997.00507.x. PMID 9346309.
• Youn BS, Zhang SM, Broxmeyer HE; et al. (1998). "Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1.". Blood 91 (9): 3118–26. PMID 9558365.
• Nardelli B, Tiffany HL, Bong GW; et al. (1999). "Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1.". J. Immunol. 162 (1): 435–44. PMID 9886417.
• Shaw KT, Greig NH (1999). "Chemokine receptor mRNA expression at the in vitro blood–brain barrier during HIV infection.". NeuroReport 10 (1): 53–6. doi:10.1097/00001756-199901180-00010. PMID 10094132.
• Zhang S, Youn BS, Gao JL; et al. (1999). "Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1.". J. Immunol. 162 (8): 4938–42. PMID 10202040.
• Lalani AS, Masters J, Zeng W; et al. (1999). "Use of chemokine receptors by poxviruses.". Science 286 (5446): 1968–71. doi:10.1126/science.286.5446.1968. PMID 10583963.

External links

• "Chemokine Receptors: CCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.