Melanocortin 5 receptor

Melanocortin 5 receptor
Identifiers
Symbols MC5R ; MC2
External IDs OMIM: 600042 MGI: 99420 HomoloGene: 4321 IUPHAR: 286 ChEMBL: 4608 GeneCards: MC5R Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4161 17203
Ensembl ENSG00000176136 ENSMUSG00000007480
UniProt P33032 G3UWB6
RefSeq (mRNA) NM_005913 NM_013596
RefSeq (protein) NP_005904 NP_038624
Location (UCSC) Chr 18:
13.82 – 13.83 Mb		 Chr 18:
68.34 – 68.34 Mb
PubMed search

Melanocortin receptor 5 is a protein that in humans is encoded by the MC5R gene.[1][2] It is located on the chromosome 18 in the human genome.[2] When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.[3]

Physiology

MC5R is necessary for normal sebum production.[3][4] Stimulation of MC5R promotes fatty acid oxidation in skeletal muscle.[5]

See also

References

  1. ↑ Chhajlani V, Muceniece R, Wikberg JE (September 1993). "Molecular cloning of a novel human melanocortin receptor". Biochemical and Biophysical Research Communications 195 (2): 866–73. doi:10.1006/bbrc.1993.2125. PMID 8396929.
  2. 1 2 "Entrez Gene: MC5R melanocortin 5 receptor".
  3. 1 2 Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson G (October 2000). "The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells". The Journal of Investigative Dermatology 115 (4): 614–9. doi:10.1046/j.1523-1747.2000.00094.x. PMID 10998132.
  4. ↑ Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD (December 1997). "Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides". Cell 91 (6): 789–98. doi:10.1016/S0092-8674(00)80467-5. PMID 9413988.
  5. ↑ An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT, Lim SK (February 2007). "Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle". The Journal of Biological Chemistry 282 (5): 2862–70. doi:10.1074/jbc.M603454200. PMID 17127674.

Further reading

  • Fathi Z, Iben LG, Parker EM (January 1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype". Neurochemical Research 20 (1): 107–13. doi:10.1007/BF00995160. PMID 7739752. 
  • Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics 68 (1-2): 79–81. doi:10.1159/000133895. PMID 7956366. 
  • Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P (April 1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor". Biochemical and Biophysical Research Communications 200 (2): 1007–14. doi:10.1006/bbrc.1994.1550. PMID 8179577. 
  • Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson CJ, Yamada T (May 1994). "Molecular cloning, expression, and characterization of a fifth melanocortin receptor". Biochemical and Biophysical Research Communications 200 (3): 1214–20. doi:10.1006/bbrc.1994.1580. PMID 8185570. 
  • Chhajlani V (February 1996). "Distribution of cDNA for melanocortin receptor subtypes in human tissues". Biochemistry and Molecular Biology International 38 (1): 73–80. PMID 8932521. 
  • Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, Barsh GS, Gantz I (March 1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Molecular Endocrinology 11 (3): 274–80. doi:10.1210/me.11.3.274. PMID 9058374. 
  • Frändberg PA, Xu X, Chhajlani V (July 1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH". Biochemical and Biophysical Research Communications 236 (2): 489–92. doi:10.1006/bbrc.1997.6994. PMID 9240466. 
  • Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I (January 1999). "Characterization of Agouti-related protein binding to melanocortin receptors". Molecular Endocrinology 13 (1): 148–55. doi:10.1210/me.13.1.148. PMID 9892020. 
  • Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL (April 2001). "Expression, candidate gene, and population studies of the melanocortin 5 receptor". The Journal of Investigative Dermatology 116 (4): 564–70. doi:10.1046/j.0022-202x.2001.01286.x. PMID 11286624. 
  • Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH (October 2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro". Journal of Medicinal Chemistry 44 (22): 3665–72. doi:10.1021/jm010165y. PMID 11606131. 
  • Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE (January 2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Molecular Pharmacology 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082. 
  • Lohoff FW, Berrettini WH (December 2005). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder". Psychiatric Genetics 15 (4): 255–8. doi:10.1097/00041444-200512000-00007. PMID 16314755. 
  • Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ (June 2007). "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5". Peptides 28 (6): 1191–6. doi:10.1016/j.peptides.2007.02.012. PMC 1955225. PMID 17482720. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia - version of the Tuesday, May 03, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.