CCR4

Chemokine (C-C motif) receptor 4
Identifiers
Symbols	CCR4 ; CC-CKR-4; CD194; CKR4; CMKBR4; ChemR13; HGCN:14099; K5-5
External IDs	OMIM: 604836 MGI: 107824 HomoloGene: 21135 IUPHAR: 61 ChEMBL: 2414 GeneCards: CCR4 Gene
EC number	3.1.13.4
Gene ontology Molecular function • chemokine receptor activity • C-C chemokine receptor activity Cellular component • cytosol • plasma membrane • integral component of plasma membrane • external side of plasma membrane Biological process • neuron migration • tolerance induction • chemotaxis • inflammatory response • immune response • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • chemokine-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1233	12773
Ensembl	ENSG00000183813	ENSMUSG00000047898
UniProt	P51679	P51680
RefSeq (mRNA)	NM_005508	NM_009916
RefSeq (protein)	NP_005499	NP_034046
Location (UCSC)	Chr 3: 32.95 – 32.96 Mb	Chr 9: 114.49 – 114.5 Mb
PubMed search

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene.^[1][2][3] CCR4 has also recently been designated CD194 (cluster of differentiation 194).

The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines:

• CCL2 (MCP-1)
• CCL4 (MIP-1)
• CCL5 (RANTES)
• CCL17 (TARC)^[4]
• CCL22 (Macrophage-derived chemokine)^[5]

Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.^[3]

References

1. Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J Biol Chem 270 (33): 19495–500. doi:10.1074/jbc.270.33.19495. PMID 7642634.
2. Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID 8884276.
3. "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4".
4. Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.
5. Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.

External links

• CCR4 receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
• "Chemokine Receptors: CCR4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.