CD11c

Integrin, alpha X (complement component 3 receptor 4 subunit)
PDB rendering based on 1n3y.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1N3Y​, 2LUV​, 3K6S​, 3K71​, 3K72​, 4NEH​, 4NEN​
Identifiers
Symbols	ITGAX ; CD11C; SLEB6
External IDs	OMIM: 151510 MGI: 96609 HomoloGene: 55493 ChEMBL: 4733 GeneCards: ITGAX Gene
Gene ontology Molecular function • receptor activity • protein binding • metal ion binding Cellular component • plasma membrane • integrin complex • cell surface • membrane Biological process • cell adhesion • integrin-mediated signaling pathway • blood coagulation • organ morphogenesis • extracellular matrix organization • heterotypic cell-cell adhesion • leukocyte migration • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3687	16411
Ensembl	ENSG00000140678	ENSMUSG00000030789
UniProt	P20702	Q9QXH4
RefSeq (mRNA)	NM_000887	NM_021334
RefSeq (protein)	NP_000878	NP_067309
Location (UCSC)	Chr 16: 31.36 – 31.38 Mb	Chr 7: 128.13 – 128.15 Mb
PubMed search

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .^{[1] [2]}

CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.^[1]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

See also

• Integrin

References

1. "Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)".
2. "Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometry".

Further reading

• Stewart M, Thiel M, Hogg N (1996). "Leukocyte integrins.". Curr. Opin. Cell Biol. 7 (5): 690–6. doi:10.1016/0955-0674(95)80111-1. PMID 8573344.
• Steinman RM, Pack M, Inaba K (1997). "Dendritic cells in the T-cell areas of lymphoid organs.". Immunol. Rev. 156 (1): 25–37. doi:10.1111/j.1600-065X.1997.tb00956.x. PMID 9176697.
• Córbi AL, Lopéz-Rodríguez C (1997). "CD11c integrin gene promoter activity during myeloid differentiation.". Leuk. Lymphoma 25 (5-6): 415–25. doi:10.3109/10428199709039028. PMID 9250811.
• Ugarova TP, Yakubenko VP (2001). "Recognition of fibrinogen by leukocyte integrins.". Ann. N. Y. Acad. Sci. 936 (1): 368–85. doi:10.1111/j.1749-6632.2001.tb03523.x. PMID 11460493.
• Valentin A, Lundin K, Patarroyo M, Asjö B (1990). "The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells.". J. Immunol. 144 (3): 934–7. PMID 1967280.
• Gaidano G, Bergui L, Schena M; et al. (1990). "Integrin distribution and cytoskeleton organization in normal and malignant monocytes.". Leukemia 4 (10): 682–7. PMID 1976870.
• Corbi AL, Garcia-Aguilar J, Springer TA (1990). "Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.". J. Biol. Chem. 265 (5): 2782–8. PMID 2303426.
• Corbi AL, Larson RS, Kishimoto TK; et al. (1988). "Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.". J. Exp. Med. 167 (5): 1597–607. doi:10.1084/jem.167.5.1597. PMC 2188934. PMID 3284962.
• Corbi AL, Miller LJ, O'Connor K; et al. (1988). "cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.". EMBO J. 6 (13): 4023–8. PMC 553883. PMID 3327687.
• Miller LJ, Wiebe M, Springer TA (1987). "Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins.". J. Immunol. 138 (8): 2381–3. PMID 3549901.
• Bilsland CA, Diamond MS, Springer TA (1994). "The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.". J. Immunol. 152 (9): 4582–9. PMID 7512600.
• Lecoanet-Henchoz S, Gauchat JF, Aubry JP; et al. (1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18.". Immunity 3 (1): 119–25. doi:10.1016/1074-7613(95)90164-7. PMID 7621072.
• Garcìa-Barcina M, Winnock M, Bidaurrazaga I; et al. (1994). "Detection of cell-adhesion molecules on human liver-associated lymphocytes.". Immunology 82 (1): 95–8. PMC 1414860. PMID 8045597.
• Philippeaux MM, Vesin C, Tacchini-Cottier F, Piguet PF (1996). "Activated human platelets express beta2 integrin.". Eur. J. Haematol. 56 (3): 130–7. doi:10.1111/j.1600-0609.1996.tb01331.x. PMID 8598231.
• de Vree WJ, Fontijne-Dorsman AN, Koster JF, Sluiter W (1996). "Photodynamic treatment of human endothelial cells promotes the adherence of neutrophils in vitro.". Br. J. Cancer 73 (11): 1335–40. doi:10.1038/bjc.1996.255. PMC 2074486. PMID 8645576.
• Bernstein CN, Sargent M, Gallatin WM (1998). "Beta2 integrin/ICAM expression in Crohn's disease.". Clin. Immunol. Immunopathol. 86 (2): 147–60. doi:10.1006/clin.1997.4462. PMID 9473377.
• Shelley CS, Da Silva N, Georgakis A; et al. (1998). "Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb.". Genomics 49 (2): 334–6. doi:10.1006/geno.1998.5232. PMID 9598326.

External links

• CD11c Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)
• Mouse CD Antigen Chart
• Human CD Antigen Chart
• ITGAX Info with links in the Cell Migration Gateway

This article incorporates text from the United States National Library of Medicine, which is in the public domain.