Kinase insert domain receptor

Kinase insert domain receptor
Rendering of 1VR2​
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1VR2​, 1Y6A​, 1Y6B​, 1YWN​, 2M59​, 2MET​, 2MEU​, 2OH4​, 2P2H​, 2P2I​, 2QU5​, 2QU6​, 2RL5​, 2X1W​, 2X1X​, 2XIR​, 3B8Q​, 3B8R​, 3BE2​, 3C7Q​, 3CJF​, 3CJG​, 3CP9​, 3CPB​, 3CPC​, 3DTW​, 3EFL​, 3EWH​, 3KVQ​, 3S35​, 3S36​, 3S37​, 3U6J​, 3V2A​, 3V6B​, 3VHE​, 3VHK​, 3VID​, 3VNT​, 3VO3​, 4AG8​, 4AGC​, 4AGD​, 4ASD​, 4ASE​
Identifiers
Symbols	KDR ; CD309; FLK1; VEGFR; VEGFR2
External IDs	OMIM: 191306 MGI: 96683 HomoloGene: 55639 ChEMBL: 279 GeneCards: KDR Gene
EC number	2.7.10.1
Gene ontology Molecular function • protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • vascular endothelial growth factor-activated receptor activity • integrin binding • protein binding • ATP binding • growth factor binding • vascular endothelial growth factor binding • Hsp90 protein binding Cellular component • extracellular region • nucleus • endosome • early endosome • endoplasmic reticulum • Golgi apparatus • plasma membrane • integral component of plasma membrane • external side of plasma membrane • cytoplasmic membrane-bounded vesicle • cell junction • membrane raft • sorting endosome Biological process • angiogenesis • ovarian follicle development • vasculogenesis • positive regulation of protein phosphorylation • positive regulation of endothelial cell proliferation • lymph vessel development • cell migration involved in sprouting angiogenesis • positive regulation of mesenchymal cell proliferation • endothelium development • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell proliferation • regulation of cell shape • positive regulation of endothelial cell migration • positive regulation of phosphatidylinositol 3-kinase signaling • viral process • peptidyl-tyrosine phosphorylation • signal transduction by protein phosphorylation • extracellular matrix organization • positive regulation of cell migration • embryonic hemopoiesis • calcium-mediated signaling using intracellular calcium source • cellular response to vascular endothelial growth factor stimulus • peptidyl-tyrosine autophosphorylation • vascular endothelial growth factor signaling pathway • negative regulation of apoptotic process • surfactant homeostasis • positive regulation of MAPK cascade • cell fate commitment • endothelial cell differentiation • regulation of endothelial cell differentiation • positive regulation of angiogenesis • protein autophosphorylation • vascular endothelial growth factor receptor signaling pathway • lung alveolus development • cell maturation • branching morphogenesis of an epithelial tube • positive regulation of positive chemotaxis • positive regulation of nitric-oxide synthase biosynthetic process • positive regulation of focal adhesion assembly • calcium ion homeostasis • positive regulation of ERK1 and ERK2 cascade • regulation of hematopoietic progenitor cell differentiation • negative regulation of endothelial cell apoptotic process • positive regulation of vasculogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3791	16542
Ensembl	ENSG00000128052	ENSMUSG00000062960
UniProt	P35968	Q8VCD0
RefSeq (mRNA)	NM_002253	NM_010612
RefSeq (protein)	NP_002244	NP_034742
Location (UCSC)	Chr 4: 55.08 – 55.13 Mb	Chr 5: 75.93 – 75.98 Mb
PubMed search

Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).

Interactions

Kinase insert domain receptor has been shown to interact with SHC2,^[1] Annexin A5^[2] and SHC1.^[3][4]

See also

• Cluster of differentiation
• VEGF receptors

Further reading

• Holmes K, Roberts OL, Thomas AM, Cross MJ. (October 2007). "Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.". Cell Signal. 19 (10): 2003–2012. doi:10.1016/j.cellsig.2007.05.013. PMID 17658244.
• Petrova TV, Makinen T, Alitalo K (1999). "Signaling via vascular endothelial growth factor receptors.". Exp. Cell Res. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
• Wang J, Fu X, Jiang C, Yu L, Wang M, Han W, Liu L, Wang J. (2014). "Bone marrow mononuclear cell transplantation promotes therapeutic angiogenesis via upregulation of the VEGF-VEGFR2 signaling pathway in a rat model of vascular dementia.". Behav. Brain Res. 265: 171–180. doi:10.1016/j.bbr.2014.02.033. PMC 4000455. PMID 24589546.
• Sato Y, Kanno S, Oda N, et al. (2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction.". Ann. N. Y. Acad. Sci. 902 (1): 201–5; discussion 205–7. doi:10.1111/j.1749-6632.2000.tb06314.x. PMID 10865839.
• Zachary I, Gliki G (2001). "Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.". Cardiovasc. Res. 49 (3): 568–81. doi:10.1016/S0008-6363(00)00268-6. PMID 11166270.
• Vené R, Benelli R, Noonan DM, Albini A (2001). "HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis.". Clin. Exp. Metastasis 18 (7): 533–8. doi:10.1023/A:1011991906685. PMID 11688957.
• Lenton K (2003). "VEGFR-2 (KDR/Flk-1).". J. Biol. Regul. Homeost. Agents 16 (3): 227–32. PMID 12456025.
• Matsumoto T, Mugishima H (2006). "Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis.". J. Atheroscler. Thromb. 13 (3): 130–5. doi:10.5551/jat.13.130. PMID 16835467.

References

1. Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (April 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. (England) 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680.
2. Wen, Y; Edelman J L; Kang T; Sachs G (May 1999). "Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1". Biochem. Biophys. Res. Commun. (UNITED STATES) 258 (3): 713–21. doi:10.1006/bbrc.1999.0678. ISSN 0006-291X. PMID 10329451.
3. Zanetti, Adriana; Lampugnani Maria Grazia; Balconi Giovanna; Breviario Ferruccio; Corada Monica; Lanfrancone Luisa; Dejana Elisabetta (April 2002). "Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling". Arterioscler. Thromb. Vasc. Biol. (United States) 22 (4): 617–22. doi:10.1161/01.ATV.0000012268.84961.AD. PMID 11950700.
4. D'Angelo, G; Martini J F; Iiri T; Fantl W J; Martial J; Weiner R I (May 1999). "16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells". Mol. Endocrinol. (UNITED STATES) 13 (5): 692–704. doi:10.1210/mend.13.5.0280. ISSN 0888-8809. PMID 10319320.

External links

• Kinase insert domain receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.