C5a receptor

Complement component 5a receptor 1
Identifiers
Symbols	C5AR1 ; C5A; C5AR; C5R1; CD88
External IDs	OMIM: 113995 MGI: 88232 HomoloGene: 20413 IUPHAR: 32 ChEMBL: 2373 GeneCards: C5AR1 Gene
Gene ontology Molecular function • complement component C5a binding • complement component C5a receptor activity • C5a anaphylatoxin receptor activity Cellular component • cytosol • plasma membrane • integral component of plasma membrane • cell surface • cytoplasmic membrane-bounded vesicle • basolateral plasma membrane • apical part of cell Biological process • activation of MAPK activity • apoptotic process • chemotaxis • inflammatory response • immune response • cellular defense response • signal transduction • activation of phospholipase C activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • positive regulation of vascular endothelial growth factor production • positive regulation of macrophage chemotaxis • cell proliferation in hindbrain • neutrophil chemotaxis • organ regeneration • response to peptidoglycan • response to lipopolysaccharide • complement component C5a signaling pathway • mRNA transcription from RNA polymerase II promoter • negative regulation of neuron apoptotic process • positive regulation of angiogenesis • positive regulation of epithelial cell proliferation • defense response to Gram-positive bacterium • positive regulation of ERK1 and ERK2 cascade • positive regulation of neutrophil chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	728	12273
Ensembl	ENSG00000197405	ENSMUSG00000049130
UniProt	P21730	P30993
RefSeq (mRNA)	NM_001736	NM_001173550
RefSeq (protein)	NP_001727	NP_001167021
Location (UCSC)	Chr 19: 47.29 – 47.32 Mb	Chr 7: 16.25 – 16.26 Mb
PubMed search

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor.^[1]

C5a receptor structure and its residues possessing role in ligand binding or signaling.

Cells

The C5a receptor is expressed on:^[2]

• Granulocytes
• Monocytes
• Dendritic cells
• Hepatoma-derived cell line HepG2
• Astrocytes
• Microglia

See also

• Complement component 5a for binding mechanism

References

1. Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology 12: 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
2. Klos A, Wende E, Wareham KJ, Monk PN (Jan 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.

Further reading

• Sengeløv H (1996). "Complement receptors in neutrophils". Critical Reviews in Immunology 15 (2): 107–31. doi:10.1615/critrevimmunol.v15.i2.10. PMID 8573284.
• Beil WJ, Schulz M, Wefelmeyer U (Jul 2000). "Mast cell granule composition and tissue location--a close correlation". Histology and Histopathology 15 (3): 937–46. PMID 10963136.
• Yamamoto T (Jan 2007). "Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes". Pathology International 57 (1): 1–11. doi:10.1111/j.1440-1827.2007.02049.x. PMID 17199736.
• Bao L, Gerard NP, Eddy RL, Shows TB, Gerard C (Jun 1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600.
• Gerard NP, Gerard C (Feb 1991). "The chemotactic receptor for human C5a anaphylatoxin". Nature 349 (6310): 614–7. doi:10.1038/349614a0. PMID 1847994.
• Boulay F, Mery L, Tardif M, Brouchon L, Vignais P (Mar 1991). "Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells". Biochemistry 30 (12): 2993–9. doi:10.1021/bi00226a002. PMID 2007135.
• Wahl SM, Allen JB, Gartner S, Orenstein JM, Popovic M, Chenoweth DE, Arthur LO, Farrar WL, Wahl LM (May 1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes". Journal of Immunology 142 (10): 3553–9. PMID 2541200.
• Foreman KE, Vaporciyan AA, Bonish BK, Jones ML, Johnson KJ, Glovsky MM, Eddy SM, Ward PA (Sep 1994). "C5a-induced expression of P-selectin in endothelial cells". The Journal of Clinical Investigation 94 (3): 1147–55. doi:10.1172/JCI117430. PMC 295185. PMID 7521884.
• Giannini E, Brouchon L, Boulay F (Aug 1995). "Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo". The Journal of Biological Chemistry 270 (32): 19166–72. doi:10.1074/jbc.270.32.19166. PMID 7642584.
• Buhl AM, Osawa S, Johnson GL (Aug 1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". The Journal of Biological Chemistry 270 (34): 19828–32. doi:10.1074/jbc.270.34.19828. PMID 7649993.
• Wennogle LP, Conder L, Winter C, Braunwalder A, Vlattas S, Kramer R, Cioffi C, Hu SI (Jul 1994). "Stabilization of C5a receptor--G-protein interactions through ligand binding". Journal of Cellular Biochemistry 55 (3): 380–8. doi:10.1002/jcb.240550316. PMID 7962171.
• Gerard NP, Bao L, Xiao-Ping H, Eddy RL, Shows TB, Gerard C (Feb 1993). "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene". Biochemistry 32 (5): 1243–50. doi:10.1021/bi00056a007. PMID 8383526.
• Ames RS, Li Y, Sarau HM, Nuthulaganti P, Foley JJ, Ellis C, Zeng Z, Su K, Jurewicz AJ, Hertzberg RP, Bergsma DJ, Kumar C (Aug 1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". The Journal of Biological Chemistry 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752.
• Werfel T, Zwirner J, Oppermann M, Sieber A, Begemann G, Drommer W, Kapp A, Götze O (Aug 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin". Journal of Immunology 157 (4): 1729–35. PMID 8759762.
• Höpken UE, Lu B, Gerard NP, Gerard C (Sep 1996). "The C5a chemoattractant receptor mediates mucosal defence to infection". Nature 383 (6595): 86–9. doi:10.1038/383086a0. PMID 8779720.
• Chen Z, Zhang X, Gonnella NC, Pellas TC, Boyar WC, Ni F (Apr 1998). "Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin". The Journal of Biological Chemistry 273 (17): 10411–9. doi:10.1074/jbc.273.17.10411. PMID 9553099.
• Floreani AA, Heires AJ, Welniak LA, Miller-Lindholm A, Clark-Pierce L, Rennard SI, Morgan EL, Sanderson SD (May 1998). "Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke". Journal of Immunology 160 (10): 5073–81. PMID 9590258.
• Ottonello L, Corcione A, Tortolina G, Airoldi I, Albesiano E, Favre A, D'Agostino R, Malavasi F, Pistoia V, Dallegri F (Jun 1999). "rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues". Journal of Immunology 162 (11): 6510–7. PMID 10352266.
• Kohleisen B, Shumay E, Sutter G, Foerster R, Brack-Werner R, Nuesse M, Erfle V (Dec 1999). "Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes". Aids 13 (17): 2331–41. doi:10.1097/00002030-199912030-00004. PMID 10597774.
• Monk PN, Scola AM, Madala P, Fairlie DP (Oct 2007). "Function, structure and therapeutic potential of complement C5a receptors". British Journal of Pharmacology 152 (4): 429–48. doi:10.1038/sj.bjp.0707332. PMC 2050825. PMID 17603557.

External links

• "Anaphylatoxin Receptors: C5a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• C5a receptors at the US National Library of Medicine Medical Subject Headings (MeSH)